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Science 15 June 1962:
Vol. 136. no. 3520, pp. 979 - 980
DOI: 10.1126/science.136.3520.979
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Articles

Localization of Two Genetic Factors to Different Areas of ggr-Globulin Molecules

M. Harboe 1, C. K. Osterland 1, and H. G. Kunkel 1

1 Rockefeller Institute, New York 21

Gm(a) and Gm(b) factors are present in 7S ggr-globulin molecules and absent in 19S ggr-globulins, beta2A-globulins and Bence-Jones proteins, whereas the Inv(b) factor was demonstrated in all four kinds of proteins. The Inv type was identical in isolated 7S and 19S ggr-globulins of six normal sera. After papain splitting of 7S ggr-globulin, Gm determining sites were present only in the fast (F) split product and Inv determining sites were present only in the slow (S).


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Inv(1) Allotype: Effect of Immunoglobulin G Heavy Chain Subtype on Its Expression.
A. G. Steinberg and I. Rostenberg (1969)
Science 164, 1072-1073
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Genetic Factors and Polypeptide Chain Subclasses of Human Immunoglobulin G Detected in Chimpanzee Serums.
F. P. Alepa and W. D. Terry (1965)
Science 150, 1293-1294
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Antibodies and Immunoglobulins: I. Structure and Function.
J. L. Fahey (1965)
JAMA 194, 71-74
   Abstract »    PDF »
Congenital Hypogammaglobulinemia.
D. E. COMINGS (1965)
Arch Intern Med 115, 79-87
   Abstract »    PDF »
Subclasses of Human ggr2-Globulin Based on Differences in the Heavy Polypeptide Chains.
W. D. Terry and J. L. Fahey (1964)
Science 146, 400-401
   Abstract »    PDF »
Dependence of a Gm(b) Antigen on the Quaternary Structure of Human Gamma Globulin.
S. H. Polmar and A. G. Steinberg (1964)
Science 145, 928-929
   Abstract »    PDF »
Gamma Globulin Antigenic Types Defined by Heavy Chain Determinants.
R. E. Ballieux, G. M. Bernier, K. Tominaga, and F. W. Putnam (1964)
Science 145, 168-170
   Abstract »    PDF »
Molecular and Submolecular Localization of Two Isoantigens of Mouse Immunoglobulins.
R. I. Mishell and J. L. Fahey (1964)
Science 143, 1440-1442
   Abstract »    PDF »
Genetic Characters and the Polypeptide Chains of Various Types of Gamma-Globulin.
H. G. Kunkel, J. C. Allen, and H. M. Grey (1964)
Cold Spring Harb Symp Quant Biol 29, 443-447
   Abstract »    PDF »
Population, Immunogenetic, and Biochemical Studies on the Gm(b) Factors of Human Gamma Globulin.
A. G. Steinberg (1964)
Cold Spring Harb Symp Quant Biol 29, 449-454
   Abstract »    PDF »
Human Gamma Globulin: Genetic Control and Its Relation to Disease.
H. FUDENBERG and E. C. FRANKLIN (1963)
Ann Intern Med 58, 171-180
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)