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Science 20 April 1962:
Vol. 136. no. 3512, pp. 257 - 258
DOI: 10.1126/science.136.3512.257
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Articles

Enhancement of Cesium-137 Excretion by Rats Treated with Acetazolamide

B. V. Ram Sastry 1 and Milton T. Bush 1

1 Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee

Acetazolamide (10 mg/kg, intraperitoneally) increases the urinary excretion of cesium-137 in the rat. Meralluride (6.8 mg of Hg per kilogram, subcutaneously) blocks the effect of acetazolamide on the cesium-137 excretion without any influence on the urine volume and pH of the urine. This indicates that acetazolamide increases the urinary excretion of cesium-137 by increasing its secretion through the renal tubule in the same manner as it increases the excretion of potassium and rubidium-86.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)