Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 30 March 1962:
Vol. 135. no. 3509, pp. 1127 - 1128
DOI: 10.1126/science.135.3509.1127
Prev | Table of Contents | Next

Articles

Are New Neurons Formed in the Brains of Adult Mammals?

Joseph Altman 1

1 Psychophysiological Laboratory, Massachusetts Institute of Technology, Cambridge 39, Massachusetts

In an autoradiographic investigation, the production of brain lesions in rats was combined with intracranial injection of thymidine-H3. Nuclei of numerous glia cells were found labeled in brain regions associated with the traumatized areas. In addition, some neurons and neuroblasts showed labeling, suggesting the possibility of proliferation of neurons in adult rats.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
A Critical Period for Activity-Dependent Synaptic Development during Olfactory Bulb Adult Neurogenesis.
W. Kelsch, C.-W. Lin, C. P. Mosley, and C. Lois (2009)
J. Neurosci. 29, 11852-11858
   Abstract »    Full Text »    PDF »
Reelin and Notch1 Cooperate in the Development of the Dentate Gyrus.
M. Sibbe, E. Forster, O. Basak, V. Taylor, and M. Frotscher (2009)
J. Neurosci. 29, 8578-8585
   Abstract »    Full Text »    PDF »
Epigenetic mechanisms regulating fate specification of neural stem cells.
M. Namihira, J. Kohyama, M. Abematsu, and K. Nakashima (2008)
Phil Trans R Soc B 363, 2099-2109
   Abstract »    Full Text »    PDF »
Neurogenin 2 has an essential role in development of the dentate gyrus.
C. Galichet, F. Guillemot, and C. M. Parras (2008)
Development 135, 2031-2041
   Abstract »    Full Text »    PDF »
The Relationship between Nature of Social Change, Age, and Position of New Neurons and Their Survival in Adult Zebra Finch Brain.
E. Adar, F. Nottebohm, and A. Barnea (2008)
J. Neurosci. 28, 5394-5400
   Abstract »    Full Text »    PDF »
Brain Plasticity Mechanisms and Memory: A Party of Four.
E. Bruel-Jungerman, S. Davis, and S. Laroche (2007)
Neuroscientist 13, 492-505
   Abstract »    PDF »
Social domination increases neuronal survival in the brain of juvenile crayfish Procambarus clarkii.
C.-K. Song, L. M. Johnstone, M. Schmidt, C. D. Derby, and D. H. Edwards (2007)
J. Exp. Biol. 210, 1311-1324
   Abstract »    Full Text »    PDF »
High Levels of New Neuron Addition Persist When the Sensitive Period for Song Learning Is Experimentally Prolonged.
L. Wilbrecht, H. Williams, N. Gangadhar, and F. Nottebohm (2006)
J. Neurosci. 26, 9135-9141
   Abstract »    Full Text »    PDF »
Chronic alcohol exposure alters transcription broadly in a key integrative brain nucleus for homeostasis: the nucleus tractus solitarius.
M. Y. Covarrubias, R. L. Khan, R. Vadigepalli, J. B. Hoek, and J. S. Schwaber (2005)
Physiol Genomics 24, 45-58
   Abstract »    Full Text »    PDF »
Huntington's disease and neurogenesis: FGF-2 to the rescue?.
A. R. La Spada (2005)
PNAS 102, 17889-17890
   Full Text »    PDF »
Adult Neurogenesis: From Precursors to Network and Physiology.
D. N. Abrous, M. Koehl, and M. Le Moal (2005)
Physiol Rev 85, 523-569
   Abstract »    Full Text »    PDF »
New GABAergic interneurons in the adult neocortex and striatum are generated from different precursors.
A. G. Dayer, K. M. Cleaver, T. Abouantoun, and H. A. Cameron (2005)
J. Cell Biol. 168, 415-427
   Abstract »    Full Text »    PDF »
Information Processing in the Mammalian Olfactory System.
P.-M. Lledo, G. Gheusi, and J.-D. Vincent (2005)
Physiol Rev 85, 281-317
   Abstract »    Full Text »    PDF »
From the Cover: Robust in vivo gene transfer into adult mammalian neural stem cells by lentiviral vectors.
A. Consiglio, A. Gritti, D. Dolcetta, A. Follenzi, C. Bordignon, F. H. Gage, A. L. Vescovi, and L. Naldini (2004)
PNAS 101, 14835-14840
   Abstract »    Full Text »    PDF »
Spatial memory performances of aged rats in the water maze predict levels of hippocampal neurogenesis.
E. Drapeau, W. Mayo, C. Aurousseau, M. Le Moal, P.-V. Piazza, and D. N. Abrous (2003)
PNAS 100, 14385-14390
   Abstract »    Full Text »    PDF »
Environment temperature affects cell proliferation in the spinal cord and brain of juvenile turtles.
M. Radmilovich, A. Fernandez, and O. Trujillo-Cenoz (2003)
J. Exp. Biol. 206, 3085-3093
   Abstract »    Full Text »    PDF »
Hippocampal Neurogenesis Follows Kainic Acid-Induced Apoptosis in Neonatal Rats.
H. Dong, C. A. Csernansky, B. Goico, and J. G. Csernansky (2003)
J. Neurosci. 23, 1742-1749
   Abstract »    Full Text »    PDF »
Neuronal migration and molecular conservation with leukocyte chemotaxis.
Y. Rao, K. Wong, M. Ward, C. Jurgensen, and J. Y. Wu (2002)
Genes & Dev. 16, 2973-2984
   Full Text »    PDF »
Neurology: Then, Now, and in the Future.
G. M. McKhann (2002)
Arch Neurol 59, 1369-1373
   Full Text »    PDF »
Nicotine Self-Administration Impairs Hippocampal Plasticity.
D. N. Abrous, W. Adriani, M.-F. Montaron, C. Aurousseau, G. Rougon, M. Le Moal, and P. V. Piazza (2002)
J. Neurosci. 22, 3656-3662
   Abstract »    Full Text »    PDF »
Neurogenesis in the Adult Brain.
F. H. Gage (2002)
J. Neurosci. 22, 612-613
   Full Text »    PDF »
Neurogenesis in Adult Mammals: Some Progress and Problems.
E. Gould and C. G. Gross (2002)
J. Neurosci. 22, 619-623
   Full Text »    PDF »
Comparative Views of Adult Neurogenesis.
N. B. Hastings, P. Tanapat, and E. Gould (2000)
Neuroscientist 6, 315-325
   Abstract »    PDF »
Mammalian Neural Stem Cells.
F. H. Gage (2000)
Science 287, 1433-1438
   Abstract »    Full Text »
Epidermal and Fibroblast Growth Factors Behave as Mitogenic Regulators for a Single Multipotent Stem Cell-Like Population from the Subventricular Region of the Adult Mouse Forebrain.
A. Gritti, P. Frolichsthal-Schoeller, R. Galli, E. A. Parati, L. Cova, S. F. Pagano, C. R. Bjornson, and A. L. Vescovi (1999)
J. Neurosci. 19, 3287-3297
   Abstract »    Full Text »    PDF »
Neurogenesis, cell death and regeneration in the adult gymnotiform brain.
G. Zupanc (1999)
J. Exp. Biol. 202, 1435-1446
   Abstract »    PDF »
Dopaminergic Neurons Intrinsic to the Primate Striatum.
R. Betarbet, R. Turner., V. Chockkan, M. R. DeLong, K. A. Allers, J. Walters, A. I. Levey, and J. T. Greenamyre (1997)
J. Neurosci. 17, 6761-6768
   Abstract »    Full Text »    PDF »
Limits of neurogenesis in primates.
P Rakic (1985)
Science 227, 1054-1056
   Abstract »    PDF »
Neurons generated in the adult brain are recruited into functional circuits.
J. Paton and F. Nottebohm (1984)
Science 225, 1046-1048
   Abstract »    PDF »
Inaugural Article: Adult-generated hippocampal and neocortical neurons in macaques have a transient existence.
E. Gould, N. Vail, M. Wagers, and C. G. Gross (2001)
PNAS 98, 10910-10917
   Abstract »    Full Text »    PDF »
Identification of a multipotent astrocytic stem cell in the immature and adult mouse brain.
E. D. Laywell, P. Rakic, V. G. Kukekov, E. C. Holland, and D. A. Steindler (2000)
PNAS 97, 13883-13888
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)