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Science 2 February 1962:
Vol. 135. no. 3501, pp. 375 - 377
DOI: 10.1126/science.135.3501.375
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Articles

Hypothalamic Control of Feeding and Self-Stimulation

Bartley G. Hoebel 1 and Philip Teitelbaum 1

1 Department of Psychology, University of Pennsylvania, Philadelphia

Hypothalamic sites which control feeding exert a corresponding control over lateral hypothalamic self-stimulation. This was demonstrated in rats bearing four, intrahypothalamic electrode-cannulas for electrical stimulation or chemical injection. Self-stimulation of the lateral hypothalamus was inhibited by ventromedial excitation or by excessive feeding. Both self-stimulation and feeding were accelerated (disinhibited) by ventromedial ablation or anesthetization. Thus food acts via the ventromedial hypothalamus to inhibit not only feeding, but also lateral hypothalamic self-stimulation.


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