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Science 10 November 1961:
Vol. 134. no. 3489, pp. 1520 - 1521
DOI: 10.1126/science.134.3489.1520
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Articles

Localized Cooling in the Brain

Vernon H. Mark 1, John C. Chato 1, Forest G. Eastman 1, Saul Aronow 1, and Frank R. Ervin 1

1 Departments of Neurosurgery and Psychiatry, Massachusetts General Hospital, and Departments of Psychiatry and Surgery, Harvard Medical School, Boston, Massachusetts

A slender refrigeration probe for the production of reversible discrete lesions within the central nervous system of man and experimental animals is described. Cooling, in the region of the third nerve nucleus in cats, produced pupillary dilatation which was quickly reversed when the temperature around the third nerve nucleus returned to normal.


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