Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 9 June 1961:
Vol. 133. no. 3467, pp. 1822 - 1823
DOI: 10.1126/science.133.3467.1822
Prev | Table of Contents | Next

Articles

Role for Ganglionic Norepinephrine in Sympathetic Synaptic Transmission

E. Costa 1, A. M. Revzin 1, R. Kuntzman 1, S. Spector 1, and B. B. Brodie 1

1 Laboratory of Chemical Pharmacology, National Heart Institute, Bethesda, Maryland

Transmission of nerve impulses in superior cervical sympathetic ganglia of cats and rabbits is markedly enhanced after reserpine-induced depletion of ganglionic norepinephrine. Transmission is also enhanced by administration of adrenergic blocking agents. In contrast, reserpine-induced release of ganglionic norepinephrine in animals pretreated with a monoamine oxidase inhibitor results in a pronounced depression of ganglionic transmission, which lasts until the ganglionic norepinephrine disappears. These results support the concept that norepinephrine in ganglia modulates the action of acetylcholine.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Dopamine-Sensitive Adenyl Cyclase: Possible Role in Synaptic Transmission.
J. W. Kebabian and P. Greengard (1971)
Science 174, 1346-1349
   Abstract »    PDF »
Pheochromocytoma--Anesthetic and Surgical Considerations.
D. L. Crandell and R. T. Myers (1964)
JAMA 187, 12-16
   Abstract »    PDF »
The Anesthetic Hazards in Patients on Antihypertensive Therapy.
D. L. Crandell (1962)
JAMA 179, 495-500
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)