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Science 3 March 1961:
Vol. 133. no. 3453, pp. 640 - 641
DOI: 10.1126/science.133.3453.640
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Articles

Plaque Reduction, a Sensitive Test for Eastern Encephalitis Antibody

Joan B. Daniels 1, Joan J. Ratner 1, and Sylvia R. Brown 1

1 Diagnostic Laboratory, Massachusetts Department of Public Health, and Department of Bacteriology, Harvard Medical School, Boston, Massachusetts

Serologic surveys of vertebrates to determine rates of eastern encephalitis infection were made to discover the most likely disseminators of virus in nature. Of the techniques available, neutralization is the most specific, and antibody is known to persist for many years. This communication reports a fivefold increase in sensitivity of neutralizing-antibody detection by the application of a plaquereducing technique.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)