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Science 14 October 1960:
Vol. 132. no. 3433, pp. 1015 - 1016
DOI: 10.1126/science.132.3433.1015
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Articles

Effect of Galactose-1-Phosphate on Glucose Oxidation by Normal and Galactosemic Leukocytes

Arnold N. Weinberg 1 and Stanton Segal 1

1 National Institute of Arthritis and Metabolic Diseases, National Institutes of Health, Bethesda, Maryland

During incubation with galactose, galactosemic leukocytes accumulated more galactose-l-phosphate than did normal leukocytes. Concomitant determination of glucose oxidation, with C14 glucose, revealed no inhibition of the hexosemonophosphate pathway. These results are at variance with recent studies in rat lens tissue, which suggests that intracellular galactose-1-phosphate depressed glucose-6-phosphate dehydrogenase activity and the oxidative pathway.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
SUGAR CATARACT.
L. T. Chylack Jr. (1972)
Arch Ophthalmol 87, 595
   Abstract »    PDF »
Physiological Chemistry of the Eye.
A. Spector (1969)
Arch Ophthalmol 81, 127-143
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Galactose Conversion to d-Xylulose: An Alternate Route of Galactose Metabolism.
P. Cuatrecasas and S. Segal (1966)
Science 153, 549-551
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)