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Science 16 September 1960:
Vol. 132. no. 3429, p. 735
DOI: 10.1126/science.132.3429.735
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Articles

On the Reported Inhibition of Monoamine Oxidase by an Agent with Sedative Properties

Sydney Spector 1, Parkhurst A. Shore 1, and Bernard B. Brodie 1

1 National Heart Institute, Bethesda, Maryland

1-Benzyl-2-methyl-5-methoxytryptamine has been reported, on the basis of indirect evidence, to inhibit monoamine oxidase. More direct experiments, however, demonstrate that the drug is devoid of the ability to block monoamine oxidase in brain in vitro or in vivo.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)