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Science 2 September 1960:
Vol. 132. no. 3427, pp. 621 - 622
DOI: 10.1126/science.132.3427.621
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Articles

Dehydrogenase Activities in Dystrophic Mice

M. W. McCaman 1

1 Institute of Psychiatric Research, and Department of Neurology, Indiana University Medical Center, Indianapolis

The levels of activity of glucose-6-phosphate dehydrogenase, isocitric dehydrogenase, glutathione reductase, lactic dehydrogenase, and a-glycerophosphate dehydrogenase have been studied in the gastrocnemius muscle of mice with "dystrophia muscularis." The activity of enzymes requiring triphosphopyridine nucleotide as a cofactor is increased relative to the control littermates, whereas the activity of those enzymes requiring diphosphopyridine nucleotide is decreased.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Cytochemical Localization of Lactate Dehydrogenase in Muscular Dystrophy of the Mouse.
H. D. Fahimi and P. Roy (1966)
Science 152, 1761-1763
   Abstract »    PDF »
Bioelectric Properties of Dystrophic Mammalian Muscle: Excitability, Membrane Resting, and Action Potentials in Mouse Hereditary Myopathy.
J. T. CONRAD and G. H. GLASER (1961)
Arch Neurol 5, 46-59
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)