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Science 26 August 1960:
Vol. 132. no. 3426, pp. 545 - 547
DOI: 10.1126/science.132.3426.545
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Articles

Transmissible Agent Associated with 26 Types of Experimental Mouse Neoplasms

Vernon Riley 1, Frank Lilly 1, Editha Huerto 1, and David Bardell 1

1 Division of Experimental Chemotherapy, Sloan-Kettering Institute for Cancer Research, New York, New York

A transmissible agent or factor has been found to be associated with all transplanted and spontaneous experimental tumors examined. This observation was made possible by utilization of a biochemical response of normal animals when inoculated with plasma or organ extracts from tumor-bearing hosts. This transmissible enzymic "lesion" is expressed by a five- to tenfold increase in the plasma lactic dehydrogenase activity of the injected normal test animals. The factor is heat labile, passes through bacteria-retaining filters, but is nondialyzable. It is partially sedimented by centrifugation at 100,000g for 1 hour.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
The LDH virus: an interfering biological contaminant.
V Riley, D. Spackman, G. Santisteban, G Dalldorf, I Hellstrom, K. Hellstrom, E. Lance, K. Rowson, B. Mahy, P Alexander, et al. (1978)
Science 200, 124-126
   PDF »
Spontaneous Mammary Tumors: Decrease of Incidence in Mice Infected with an Enzyme-Elevafing Virus.
V. Riley (1966)
Science 153, 1657-1658
   Abstract »    PDF »
Isoenzymic Specificity of Impaired Clearance in Mice Infected with Riley Virus.
B. W. J. Mahy and K. E. K. Rowson (1965)
Science 149, 756-757
   Abstract »    PDF »
Synergism between a Lactate Dehydrogenase-Elevating Virus and Eperythrozoon coccoides.
V. Riley (1964)
Science 146, 921-923
   Abstract »    PDF »
Resistance of Mice Infected with Moloney Leukemia Virus to Friend Virus Infection.
W. P. Rowe (1963)
Science 141, 40-41
   Abstract »    PDF »
Infectious Diseases: Annual Review of Significant Publications.
H. A. REIMANN (1962)
Arch Intern Med 109, 60-96
   Abstract »    PDF »


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