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Science 12 August 1960:
Vol. 132. no. 3424, pp. 419 - 420
DOI: 10.1126/science.132.3424.419
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Articles

Biological Activity of 3-Methoxy-Catecholamines

Jacques Champagne 1, Antoine D'Iorio 1, and Auréle Beaulnes 2

1 Department of Physiology, University of Montreal, Montreal, Quebec
2 Department of Pharmacology, University of Montreal

The methoxy analogs of epinephrine, norepinephrine, and dopamine manifest some activity on smooth muscle and blood pressure. Metanephrine is as potent as epinephrine on rabbit aortic strips. The same compounds demonstrate a lesser potency on rabbit duodenum preparation, while 3-methoxy-dopamine produces a slight contraction of the duodenum. Both metanephrine and 3-methoxy-dopamine have 15 to 25 percent of the pressor activity of the original nonmethylated catecholamines. Normetanephrine is 1/600 as active as norepinephrine on the blood pressure of the cat.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Differences in the Metabolism of Norepinephrine in Depressions: The Effects of Various Therapies.
S. ROSENBLATT and J.D. CHANLEY (1965)
Arch Gen Psychiatry 13, 495-502
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Science. ISSN 0036-8075 (print), 1095-9203 (online)