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Science 15 July 1960:
Vol. 132. no. 3420, pp. 151 - 152
DOI: 10.1126/science.132.3420.151
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Articles

Serial Lactic Dehydrogenase Activity in Plasma of Mice with Growing or Regressing Tumors

Vernon Riley 1 and Felix Wroblewski 1

1 Divisions of Experimental Chemotherapy and Clinical Investigation, Sloan-Kettering Institute for Cancer Research, New York, New York

Close correlation has been observed between the serially tested plasma level of a glycolytic enzyme, lactic dehydrogenase, and the growth of several transplanted mouse tumors. The character of the lactic dehydrogenase curve determined by serial blood sampling of the animals during the development of such tumors is found to consist of five separate phases. The first three appear before any visible evidence of tumor growth. Inhibition or regression of tested tumors, induced by therapeutic compounds, was accurately reflected in a corresponding reduction of lactic dehydrogenase activity in the peripheral plasma of the host.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Pretreatment Serum Lactate Dehydrogenase Predicting Metastatic Spread in Ewing's Sarcoma.
H. D. BRERETON, R. SIMON, and T. C. POMEROY (1975)
Ann Intern Med 83, 352-354
   Abstract »    PDF »
Serum Enzyme Changes During Treatment of Cancer.
B. KABAKOW, W. ANTOPOL, H. G. ALBAUM, G. BLINICK, L. GINZBURG, and R. YOUNG (1962)
Arch Intern Med 110, 331-338
   Abstract »    PDF »
Transmissible Agent Associated with 26 Types of Experimental Mouse Neoplasms.
V. Riley, F. Lilly, E. Huerto, and D. Bardell (1960)
Science 132, 545-547
   Abstract »    PDF »


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