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Science 8 July 1960:
Vol. 132. no. 3419, pp. 89 - 91
DOI: 10.1126/science.132.3419.89-a
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Articles

Uterine Vascular Clamping: New Procedure for the Study of Congenital Malformations

Robert L. Brent 1 and John B. Franklin 1

1 Department of Pediatrics, Jefferson Medical College of Philadelphia, Philadelphia, Pennsylvania

Clamping the uterine blood vessels of the rat on the 9th day of gestation for frac12 to 3 hours resulted in fetal death, growth retardation, and severe congenital malformations. This procedure has broad applications in the fields of teratology and cancer chemotherapy, and in the investigation of fetal-maternal physiology.


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