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Science 24 June 1960:
Vol. 131. no. 3417, pp. 1890 - 1891
DOI: 10.1126/science.131.3417.1890
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Articles

Decarboxylase Inhibition and Blood Pressure Reduction by agr-Methyl-3,4-Dihydroxy-DL-phenylalanine

J. A. Oates 1, L. Gillespie 1, S. Udenfriend 1, and A. Sjoerdsma 1

1 National Heart Institute, Bethesda, Maryland

agr-Methyl-3,4-dihydroxy-DLphenylalanine has been found to be an effective inhibitor of aromatic amino acid decarboxylation in man. This was shown by decreased formation of serotonin, tryptamine, and tyramine from the precursor amino acids. Reduction of amine biosynthesis is associated with lowering of blood pressure in hypertensive patients and a transient sedative effect.


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