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Science 13 May 1960:
Vol. 131. no. 3411, p. 1448
DOI: 10.1126/science.131.3411.1448
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Articles

Rapid Induction of Allergic Encephalomyelitis in Rats without the Use of Mycobacteria

Jennifer Bell 1 and Philip Y. Paterson 1

1 Department of Microbiology, New York University College of Medicine, New York, and National Institute of Allergy and Infectious Diseases, Bethesda, Maryland

Rats, in contrast to certain other species of animals reported, have a striking capacity to develop allergic encephalomyelitis within 2 to 3 weeks following one injection of spinal cord antigen combined with Freund's incomplete adjuvant—that is, adjuvant prepared without addition of killed mycobacteria.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)