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Science 13 May 1960:
Vol. 131. no. 3411, pp. 1440 - 1442
DOI: 10.1126/science.131.3411.1440
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Articles

Is Reserpine Tranquilization Linked to Change in Brain Serotonin or Brain Norepinephrine?

F. Sulser 1 and Bernard B. Brodie 1

1 Laboratory of Chemical Pharmacology, National Institutes of Health, Bethesda, Maryland

Reserpine, when administered to animals stressed by exposure to cold, does not induce sedation or appreciably lower brain serotonin, but markedly lowers brain norepinephrine. Reserpine in cold-exposed hypophysectomized rats elicits sedation and releases both amines equally. The results support the view that the tranquilizing action of reserpine is not related to brain norepinephrine loss but rather to change in the level of brain serotonin.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Basic Science Review : The Basic Pharmacologic Principles Underlying the Use of Sedatives and Tranquilizers.
J. R. Dipalma (1963)
Clinical Pediatrics 2, 225-232
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Science. ISSN 0036-8075 (print), 1095-9203 (online)