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Science 18 March 1960:
Vol. 131. no. 3403, p. 829
DOI: 10.1126/science.131.3403.829-a
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Articles

Primary Site of Gene Action Anterior Pituitary Dwarf Mice

Robert L. Carsner 1 and Edward G. Rennels 1

1 Department of Anatomy, University of Texas Medical Branch, Galveston

The transplantation of anterior pituitary glands of normal mice into hypophysectomized dwarf littermates has resulted in mice that are normal in appearance and growth rate. In contrast, the anterior pituitary gland of dwarf animals, when placed in the sella of hypophysectomized normal littermates, failed to promote the growth of these animals. These results indicate that the primary site of gene action in dwarfism lies in the anterior pituitary itself rather than in the hypothalamus.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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Genes & Dev. 17, 677-682
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Anterior pituitary cells defective in the cell-autonomous factor, df, undergo cell lineage specification but not expansion.
P. Gage, M. Roller, T. Saunders, L. Scarlett, and S. Camper (1996)
Development 122, 151-160
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Science. ISSN 0036-8075 (print), 1095-9203 (online)