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Science 11 March 1960:
Vol. 131. no. 3402, p. 726
DOI: 10.1126/science.131.3402.726
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Articles

Thrombin-E as a Fibrinolytic Enzyme

Walter H. Seegers 1, Ricardo H. Landaburu 1, and J. Frederic Johnson 1

1 Department of Physiology and Pharmacology, Wayne State University, Detroit, Michigan

Thrombin-E has been produced in adequate quantity for pharmacological studies. After intravenous infusion in dogs there were no significantchanges in blood pressure, temperature, pulse rate, and respiratory movements. There were drops in platelet and white cell count, and there was an increase in bloodsugar level. Powerful fibrinolytic phenomena wereobserved.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)