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Science 29 January 1960:
Vol. 131. no. 3396, pp. 297 - 298
DOI: 10.1126/science.131.3396.297
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Articles

Enzymatic Basis of Mannose Toxicity in Honey Bees

Alberto Sols 1, Eduardo Cadenas 1, and Francisco Alvarado 1

1 Centro de Investigaciones Biológicas, Consejo Superior de Investigaciones Cientificas, Madrid, Spain

Honey bees have a negligible amount of phosphomannoseisomerase, together with a high content of a hexokinase which phosphorylates mannose more efficiently than fructose or glucose. Competition at the phosphorylation level plus accumulation of mannose-6-phosphate can fully account for the toxicity of mannose in honey bees.


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