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Science 22 January 1960:
Vol. 131. no. 3395, pp. 226 - 227
DOI: 10.1126/science.131.3395.226
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Articles

Relationship of Stress-Induced Histidine Decarboxylase to Circulatory Homeostasis and Shock

Richard W. Schayer 1

1 Merck Institute for Therapeutic Research, Rahway, New Jersey

Histidine decarboxylase activity of mouse tissues is increased by stress and by injection of epinephrine and norepinephrine, suggesting a balance between histamine and catechol amines producing a component of circulatory homeostasis. Imbalance during intense stress might lead to failure of circulatory homeostasis and to shock. Reasons for discounting histamine as "shock toxin" may be invalid.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Influence of Reserpine and Guanethidine On Vascular Reactivity and Antihistamine Constrictor Action in the Microcirculation.
B. M. Altura and B. W. Zweifach (1966)
Angiology 17, 493-502
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Science. ISSN 0036-8075 (print), 1095-9203 (online)