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Science 1 January 1960:
Vol. 131. no. 3392, pp. 37 - 39
DOI: 10.1126/science.131.3392.37
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Articles

Mitotic Arrest by Deuterium Oxide

Paul R. Gross 1 and William Spindel 1

1 Department of Biology, New York University, New York; Department of Chemistry, Rutgers State University, Newark, New Jersey; Marine Biological Laboratory, Woods Hole, Massachusetts

In marine invertebrate eggs, where cell divisions occur without growth, deuterium oxide produces arrest of, or serious delay in, mitosis and cytokinesis. All stages requiring assembly or operation of mechanical structures in the cytoplasm are sensitive to D.O. The block is reversible in some cells.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)