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Science 27 November 1959:
Vol. 130. no. 3387, pp. 1478 - 1479
DOI: 10.1126/science.130.3387.1478
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Articles

Induced Synthesis of Liver Microsomal Enzymes Which Metabolize Foreign Compounds

A. H. CONNEY 1, JAMES R. GILLETTE 1, JOSEPH K. INSCOE 1, EBERHARD R. TRAMS 1, and HERBERT S. POSNER 1

1 National Institutes of Health, Bethesda, Maryland

The administration of 3,4-benzpyrene to rats markedly increases the activities of certain liver microsomal enzymes which metabolize foreign compounds. Evidence based on studies of enzyme induction is presented which suggests the presence in liver microsomes of several enzymes which can catalyze the same type of reaction.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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Science. ISSN 0036-8075 (print), 1095-9203 (online)