Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 27 November 1959:
Vol. 130. no. 3387, pp. 1478 - 1479
DOI: 10.1126/science.130.3387.1478
Prev | Table of Contents | Next

Articles

Induced Synthesis of Liver Microsomal Enzymes Which Metabolize Foreign Compounds

A. H. CONNEY 1, JAMES R. GILLETTE 1, JOSEPH K. INSCOE 1, EBERHARD R. TRAMS 1, and HERBERT S. POSNER 1

1 National Institutes of Health, Bethesda, Maryland

The administration of 3,4-benzpyrene to rats markedly increases the activities of certain liver microsomal enzymes which metabolize foreign compounds. Evidence based on studies of enzyme induction is presented which suggests the presence in liver microsomes of several enzymes which can catalyze the same type of reaction.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Diurnal Rhythm in Endoplasmic Reticulum of Rat Liver: Electron Microscopic Study.
A. Chedid and V. Nair (1972)
Science 175, 176-179
   Abstract »    PDF »
Cigarette Smoking: Stimulatory Effect on Metabolism of 3,4-Benzpyrene by Enzymes in Human Placenta.
R. M. Welch, Y. E. Harrison, A. H. Conney, P. J. Poppers, and M. Finster (1968)
Science 160, 541-542
   Abstract »    PDF »
Skin Tumorigenesis by 7,12-Dimethylbenz(a)anthracene: Inhibition by Actinomycin D.
H. V. Gelboin and M. Klein (1964)
Science 145, 1321-1322
   Abstract »    PDF »
A Possible Cellular Explanation of the Multiplicity of Steroid Reductases.
R. F. Bakemeier (1961)
Cold Spring Harb Symp Quant Biol 26, 379-387
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)