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Science 9 October 1959:
Vol. 130. no. 3380, pp. 918 - 919
DOI: 10.1126/science.130.3380.918
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Articles

Experimental Evidence in Support of the Dormant Tumor Cell

BERNARD FISHER 1 and EDWIN R. FISHER 1

1 Department of Surgery and Laboratory of Surgical Research and Pathology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania

When rats were injected intraportally with as few as 50 Walker-256 carcinosarcoma cells aarcoma cells and then examined 5 months later for hepatic tumor growth, none was evident. If, however, 3 months after injection the rats were subjected to repeated laparotomy and liver examination at 7-day intervals, 100 percent had a tumor within a few weeks.


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