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Science 21 August 1959:
Vol. 130. no. 3373, pp. 454 - 455
DOI: 10.1126/science.130.3373.454
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Articles

Prolactin, a Factor in Promoting Survival of Hypophysectomized Killifish in Fresh Water

GRACE E. PICKFORD 1 and JOHN G. PHILLIPS 1

1 Bingham Oceanographic Laboratory, Yale University, New Haven, Connecticut

The naturally occurring corticosteroids, cortisol and aldosterone, failed to promote survival of hypophysectomized Fundulus heteroclitus in fresh water. Extracts of Fundulus interrenal tissue, carp corpuscles of Stannius, and hog renin were ineffective. Injection of whole rat-pituitary brei was partially successful. Highly purified prolactin maintained survival, although the recipients did not eat normally. A synergic action of prolactin with some unidentified pituitary hormone is suspected.


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Science. ISSN 0036-8075 (print), 1095-9203 (online)