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Science 21 August 1959:
Vol. 130. no. 3373, pp. 453 - 454
DOI: 10.1126/science.130.3373.453
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Articles

Inhibition of O-Methyltransferase by Catechol and Sensitization to Epinephrine

ZENON M. BACQ 1, LUC GOSSELIN 1, ALBERT DRESSE 1, and JEAN RENSON 1

1 Department of General Pathology and Institute of Physiology, University of Liège, Belgium

Catechol at equimolecular concentration inhibits the inactivation of adrenaline by O-methyltransferase in vitro about 50 percent. The inhibition is probably responsible for the sensitization of smooth muscles to epinephrine by various ortho di- or triphenols.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
The Metabolism of the Catecholamines (Clinical Implications) Combined Clinical Staff Conference of the National Institutes of Health.
R. A. COHEN, W. F. BRIDGERS, J. AXELROD, H. WEIL-MALHERBE, E. H. LABROSSE, W. E. BUNNEY JR., P. V. CARDON JR., and S. S. KETY (1962)
Ann Intern Med 56, 960-987
   Abstract »    PDF »
Monoamine Oxidase and Catechol O-Methyl Transferase Inhibitors: Effect of Intradermal Injection on Exogenous and Endogenous Norepinephrine.
G. A. DeOREO and R. B. STOUGHTON (1961)
Arch Dermatol 84, 972-979
   Abstract »    PDF »
Biological Activity of 3-Methoxy-Catecholamines.
J. Champagne, A. D'Iorio, and A. Beaulnes (1960)
Science 132, 419-420
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)