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Science 21 August 1959:
Vol. 130. no. 3373, pp. 452 - 453
DOI: 10.1126/science.130.3373.452
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Articles

10-Hydroxy-Dgr2-Decenoic Acid, an Antibiotic Found in Royal Jelly

MURRAY S. BLUM 1, ARTHUR F. NOVAK 2, and STEPHEN TABER III 3

1 Entomology Research Department, Louisiana State University, Baton Rouge
2 Department of Agricultural Chemistry and Biochemistry, Louisiana State University
3 Agricultural Research Service, U.S. Department of Agriculture, Washington, D.C.

10-Hydroxy-Dgr2-decenoic acid, the major component of the lipide fraction of royal jelly, exhibits antibiotic activity against many bacteria and fungi. This fatty acid is less than one-fourth as active as penicillin against Micrococcus pyogenes and less than one-fifth as active as chlortetracycline against Escherichia coli. It also slows the growth rate of Neurospora sitophila and some unidentified molds. The salt of this compound is considerably less active than the free acid.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Estrogenic Activities of Fatty Acids and a Sterol Isolated from Royal Jelly.
K.-M. Suzuki, Y. Isohama, H. Maruyama, Y. Yamada, Y. Narita, S. Ohta, Y. Araki, T. Miyata, and S. Mishima (2008)
Evid. Based Complement. Altern. Med. 5, 295-302
   Abstract »    Full Text »    PDF »
10-Hydroxy-2-decenoic Acid, a Major Fatty Acid from Royal Jelly, Inhibits VEGF-induced Angiogenesis in Human Umbilical Vein Endothelial Cells.
H. Izuta, Y. Chikaraishi, M. Shimazawa, S. Mishima, and H. Hara (2007)
Evid. Based Complement. Altern. Med.
   Abstract »    Full Text »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)