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Science 10 July 1959:
Vol. 130. no. 3367, pp. 104 - 105
DOI: 10.1126/science.130.3367.104
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Articles

Molecular Structural Factors in Competitive Inhibition of Sugar Transport

PAUL G. LEFEVRE 1

1 Medical Research Center, Brookhaven National Laboratory, Upton, New York

The high potency of phloretin as a competitive inhibitor of the human red cell's monosaccharide transport system is not shared by any of several molecular fragments of phloretin, but is duplicated in certain artificial estrogens resembling phloretin in respect to the spacing between terminal phenolic —OH groups. Related molecules which are slightly less extendible are comparatively inactive.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Phospholipid-Sugar Complexes in Relation to Cell Membrane Monosaccharide Transport.
P. G. LeFevre, K. I. Habich, H. S. Hess, and M. R. Hudson (1964)
Science 143, 955-957
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Science. ISSN 0036-8075 (print), 1095-9203 (online)