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Science 26 June 1959:
Vol. 129. no. 3365, pp. 1741 - 1742
DOI: 10.1126/science.129.3365.1741
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Articles

Bilirubin Inhibition of Heme Biosynthesis

ROBERT F. LABBE 1, MERLIN R. ZASKE 1, and ROBERT A. ALDRICH 1

1 Department of Pediatrics, School of Medicine, University of Washington, Seattle

The conversion of protoporphyrin and iron to heme is catalyzed by a soluble enzyme prepared from rat liver. This reaction is inhibited by bilirubin, and initial kinetic studies suggest that the inhibition is due in part to a competition between protoporphyrin and the bile pigment. Implications of this finding in hyperbilirubinemia are mentioned.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)