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Science 10 April 1959:
Vol. 129. no. 3354, pp. 967 - 968
DOI: 10.1126/science.129.3354.967
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Articles

Role of Myocardial Catecholamines in Cardiac Contractility

WOO CHOO LEE 1 and F. E. SHIDEMAN 1

1 Department of Pharmacology and Toxicology, University of Wisconsin, Madison

In cats bilateral sympathectomy or administration of reserpine results in a marked reduction in concentration of myocardial catecholamines. The contractility of papillary muscles from such animals is significantly less than that of muscles from untreated animals. These findings demonstrate the importance of normal levels of myocardial catecholamines in the maintenance of normal cardiac contractility.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Reserpine: Effect on Structure of Heart Muscle.
D. E. L. Wilcken, D. Brender, C. D. Shorey, and G. J. Macdonald (1967)
Science 157, 1332-1334
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Science. ISSN 0036-8075 (print), 1095-9203 (online)