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Science 3 April 1959:
Vol. 129. no. 3353, pp. 897 - 898
DOI: 10.1126/science.129.3353.897
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Articles

Drug Metabolism in the Newborn Rabbit

JAMES R. FOUTS 1 and RICHARD H. ADAMSON 1

1 Department of Pharmacology, College of Medicine, State University of Iowa, Iowa City

A number of drugs that are metabolized through the action of enzymes present in liver microsomes in the adult rabbit are not metabolized in livers of newborn rabbits. The development of metabolic pathways during a period of 4 weeks is presented. Evidence is given for the presence in livers of baby rabbits of inhibitors of some of these drug-enzyme systems.


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Science. ISSN 0036-8075 (print), 1095-9203 (online)