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Science 27 March 1959:
Vol. 129. no. 3352, p. 844
DOI: 10.1126/science.129.3352.844
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Articles

Depression of Norepinephrine and 5-Hydroxytryptamine in the Brain by Benzoquinolizine Derivatives

A. PLETSCHER 1, H. BESENDORF 1, and K. F. GEY 1

1 Medical Research Department, F. Hoffmann-La Roche and Company, Basle, Switzerland

The effects of two benzoquinolizine derivatives on the 5-hydroxytryptamine and norepinephrine content of the brain of mice, and some pharmacological actions, are described. Certain central effects (such as sedation and narcosis potentiation) of benzoquinolizine derivatives and possibly of Rauwolfia alkaloids may be due to changes of norepinephrine metabolism rather than to changes of 5-hydroxytryptamine metabolism in the brain.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Is Reserpine Tranquilization Linked to Change in Brain Serotonin or Brain Norepinephrine?.
F. Sulser and B. B. Brodie (1960)
Science 131, 1440-1442
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