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Science 6 February 1959:
Vol. 129. no. 3345, pp. 328 - 329
DOI: 10.1126/science.129.3345.328
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Articles

Release of Autonomic Mediators in Cardiac Tissue by Suprathreshold Stimulation

ROBERT F. FURCHGOTT 1, TAISIJA DE GUBAREFF 1, and ALBERT GROSSMAN 1

1 Department of Pharmacology, State University of New York College of Medicine, Brooklyn, and Department of Pharmacology, Washington University School of Medicine, St. Louis, Missouri

Pharmacological evidence is presented supporting the theory that the increase in contractile strength of isolated cardiac muscle under suprathreshold stimulation is due to the release of an adrenergic mediator (norepinephrine). However, release of this material does not account for changes in contractile strength associated with changes in frequency of stimulation at threshold levels.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Action of Nicotine and Tobacco-Smoking on the Adrenal Medulla: A Review.
H. SILVETTE, P. S. LARSON, and H. B. HAAG (1961)
Arch Intern Med 107, 915-931
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