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Science 30 January 1959:
Vol. 129. no. 3344, pp. 275 - 276
DOI: 10.1126/science.129.3344.275
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Articles

Significance of Mitochondria for Porphyrin and Heme Biosynthesis

SEIYO SANO 1, SUSUMU INOUE 1, YOICHI TANABE 1, CHIYOO SUMIYA 1, and SHIRO KOIKE 1

1 Department of Public Health, Faculty of Medicine, Kyoto University, Kyoto, Japan

It is concluded that mitochondria are involved in three steps of porphyrin and heme biosynthesis—first, in the formation of dgr-aminolevulinic acid from glycine and active succinate; second, in the synthesis of protoporphyrin; third, in the incorporation of iron into the porphyrin ring—that is, in heme formation.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Structural basis of hereditary coproporphyria.
D.-S. Lee, E. Flachsova, M. Bodnarova, B. Demeler, P. Martasek, and C. S. Raman (2005)
PNAS 102, 14232-14237
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Science. ISSN 0036-8075 (print), 1095-9203 (online)