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Science 2 January 1959:
Vol. 129. no. 3340, pp. 42 - 43
DOI: 10.1126/science.129.3340.42
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Articles

Critical Period for Effects of Infantile Experience on Maturation of Stress Response

SEYMOUR LEVINE 1 and GEORGE W. LEWIS 1

1 Columbus Psychiatric Institute and Hospital and Ohio State University Health Center, Columbus

Manipulated infant rats respond to cold with depletion of adrenal ascorbic acid (AAA) significantly earlier than nonmanipulated infants. The study discussed in this report examined the critical period for infantile manipulation on the depletion of AAA. It was found that infant rats manipulated immediately following birth exhibited significant AAA depletion, whereas infants manipulated later did not exhibit depletion.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Down-Regulation of Hypothalamic Corticotropin-Releasing Hormone Messenger Ribonucleic Acid (mRNA) Precedes Early-Life Experience-Induced Changes in Hippocampal Glucocorticoid Receptor mRNA.
S. Avishai-Eliner, M. Eghbal-Ahmadi, E. Tabachnik, K. L. Brunson, and T. Z. Baram (2001)
Endocrinology 142, 89-97
   Abstract »    Full Text »    PDF »
Hormonal Influences on Brain Organization in Infant Rats.
S. Levine and R. F. Mullins Jr. (1966)
Science 152, 1585-1592
   PDF »
Temperature Change: The Basic Variable in the Early Handling Phenomenon?.
T. Schaefer Jr., F. S. Weingarten, and J. C. Towne (1962)
Science 135, 41-42
   Abstract »    PDF »
Critical Periods for the Effects of Infantile Experience on Adult Learning.
V. H. Denenberg and R. W. Bell (1960)
Science 131, 227-228
   Abstract »    PDF »
Differential Maturation of the Central Nervous System as a Function of Early Experience.
S. LEVINE and M. ALPERT (1959)
Arch Gen Psychiatry 1, 403-405
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)