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Published Online April 26, 2007
Science DOI: 10.1126/science.1142382

Reports

Submitted on March 12, 2007
Accepted on April 20, 2007

A Genome-Wide Association Study of Type 2 Diabetes in Finns Detects Multiple Susceptibility Variants

Laura J. Scott 1, Karen L. Mohlke 2, Lori L. Bonnycastle 3, Cristen J. Willer 1, Yun Li 1, William L. Duren 1, Michael R. Erdos 3, Heather M. Stringham 1, Peter S. Chines 3, Anne U. Jackson 1, Ludmila Prokunina-Olsson 3, Chia-Jen Ding 1, Amy J. Swift 3, Narisu Narisu 3, Tianle Hu 1, Randall Pruim 4, Rui Xiao 1, Xiao-Yi Li 1, Karen N. Conneely 1, Nancy L. Riebow 3, Andrew G. Sprau 3, Maurine Tong 3, Peggy P. White 1, Kurt N. Hetrick 5, Michael W. Barnhart 5, Craig W. Bark 5, Janet L. Goldstein 5, Lee Watkins 5, Fang Xiang 1, Jouko Saramies 6, Thomas A. Buchanan 7, Richard M. Watanabe 8, Timo T. Valle 9, Leena Kinnunen 10, Goncalo R. Abecasis 1, Elizabeth W. Pugh 5, Kimberly F. Doheny 5, Richard N. Bergman 11, Jaakko Tuomilehto 12, Francis S. Collins 3*, Michael Boehnke 1*

1 Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI 48109, USA.
2 Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA.
3 Genome Technology Branch, National Human Genome Research Institute, Bethesda, MD 20892, USA.
4 Department of Mathematics and Statistics, Calvin College, Grand Rapids, MI 49546, USA.
5 Center for Inherited Disease Research, Institute of Genetic Medicine, Johns Hopkins School of Medicine, Baltimore, MD 21224, USA.
6 Savitaipale Health Center, 54800 Savitaipale, Finland.
7 Division of Endocrinology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
8 Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA.; Department of Physiology and Biophysics, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
9 Diabetes Unit, Department of Epidemiology and Health Promotion, National Public Health Institute, 00300 Helsinki, Finland.
10 Diabetes Unit, Department of Epidemiology and Health Promotion, National Public Health Institute, 00300 Helsinki, Finland.; Department of Public Health, University of Helsinki, 00014 Helsinki, Finland.
11 Department of Physiology and Biophysics, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
12 Diabetes Unit, Department of Epidemiology and Health Promotion, National Public Health Institute, 00300 Helsinki, Finland.; Department of Public Health, University of Helsinki, 00014 Helsinki, Finland.; South Ostrobothnia Central Hospital, 60220 Seinajoki, Finland.

* To whom correspondence should be addressed.
Francis S. Collins , E-mail: francisc{at}mail.nih.gov
Michael Boehnke , E-mail: boehnke{at}umich.edu

Identifying the genetic variants that increase risk of type 2 diabetes (T2D) has been a formidable challenge. Adopting a genome wide association strategy, we genotyped 1,161 Finnish T2D cases and 1,174 Finnish normal glucose tolerant (NGT) controls with >315,000 SNPs, and imputed genotypes for an additional >2 million autosomal SNPs. We carried out association analysis with these SNPs to identify genetic variants that predispose to T2D, compared our T2D association results with results of two other such studies, and genotyped 80 SNPs in an additional 1,215 Finnish T2D cases and 1,258 Finnish NGT controls. We identify T2D-associated variants in an intergenic region of chromosome 11p12, contribute to the identification of T2D-associated variants near the genes IGF2BP2, CDKAL1, and CDKN2A/CDKN2B, and confirm that variants near TCF7L2, SLC30A8, HHEX, FTO, PPARG, and KCNJ11 are associated with T2D risk. This brings to at least ten the number of T2D loci now confidently identified.


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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
The complex genetics of multiple sclerosis: pitfalls and prospects.
S. Sawcer (2008)
Brain 131, 3118-3131
   Abstract »    Full Text »    PDF »
Interaction Between Poor Glycemic Control and 9p21 Locus on Risk of Coronary Artery Disease in Type 2 Diabetes.
A. Doria, J. Wojcik, R. Xu, E. V. Gervino, T. H. Hauser, M. T. Johnstone, D. Nolan, F. B. Hu, and J. H. Warram (2008)
JAMA 300, 2389-2397
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Genotype Score in Addition to Common Risk Factors for Prediction of Type 2 Diabetes.
J. B. Meigs, P. Shrader, L. M. Sullivan, J. B. McAteer, C. S. Fox, J. Dupuis, A. K. Manning, J. C. Florez, P. W.F. Wilson, R. B. D'Agostino Sr., et al. (2008)
N. Engl. J. Med. 359, 2208-2219
   Abstract »    Full Text »    PDF »
Clinical Risk Factors, DNA Variants, and the Development of Type 2 Diabetes.
V. Lyssenko, A. Jonsson, P. Almgren, N. Pulizzi, B. Isomaa, T. Tuomi, G. Berglund, D. Altshuler, P. Nilsson, and L. Groop (2008)
N. Engl. J. Med. 359, 2220-2232
   Abstract »    Full Text »    PDF »
Genetic Mapping in Human Disease.
D. Altshuler, M. J. Daly, and E. S. Lander (2008)
Science 322, 881-888
   Abstract »    Full Text »    PDF »
Introduction to the Special Issue on Society and Genetics.
Guang Guo (2008)
Sociological Methods Research 37, 159-163
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The Importance of Gene--Environment Interaction: Implications for Social Scientists.
K. E. North and L. J. Martin (2008)
Sociological Methods Research 37, 164-200
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Learning From Molecular Genetics: Novel Insights Arising From the Definition of Genes for Monogenic and Type 2 Diabetes.
M. I. McCarthy and A. T. Hattersley (2008)
Diabetes 57, 2889-2898
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Genes Associated With Risk of Type 2 Diabetes Identified by a Candidate-Wide Association Scan: As a Trickle Becomes a Flood.
S. S. Rich, J. M. Norris, and J. I. Rotter (2008)
Diabetes 57, 2915-2917
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Associations Between Single Nucleotide Polymorphisms on Chromosome 9p21 and Risk of Coronary Heart Disease in Chinese Han Population.
L. Zhou, X. Zhang, M. He, L. Cheng, Y. Chen, F. B. Hu, and T. Wu (2008)
Arterioscler Thromb Vasc Biol 28, 2085-2089
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Assessing the Combined Impact of 18 Common Genetic Variants of Modest Effect Sizes on Type 2 Diabetes Risk.
H. Lango, the U.K. Type 2 Diabetes Genetics Consortium, C. N.A. Palmer, A. D. Morris, E. Zeggini, A. T. Hattersley, M. I. McCarthy, T. M. Frayling, and M. N. Weedon (2008)
Diabetes 57, 3129-3135
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PCLO Variants Are Nominally Associated With Early-Onset Type 2 Diabetes and Insulin Resistance in Pima Indians.
L. Ma, R. L. Hanson, L. N. Que, Y. Guo, S. Kobes, C. Bogardus, and L. J. Baier (2008)
Diabetes 57, 3156-3160
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Fat Mass-and Obesity-Associated (FTO) Gene Variant Is Associated With Obesity: Longitudinal Analyses in Two Cohort Studies and Functional Test.
L. Qi, K. Kang, C. Zhang, R. M. van Dam, P. Kraft, D. Hunter, C.-H. Lee, and F. B. Hu (2008)
Diabetes 57, 3145-3151
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Comprehensive Association Study of Type 2 Diabetes and Related Quantitative Traits With 222 Candidate Genes.
K. J. Gaulton, C. J. Willer, Y. Li, L. J. Scott, K. N. Conneely, A. U. Jackson, W. L. Duren, P. S. Chines, N. Narisu, L. L. Bonnycastle, et al. (2008)
Diabetes 57, 3136-3144
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Common Missense Variant in the Glucokinase Regulatory Protein Gene Is Associated With Increased Plasma Triglyceride and C-Reactive Protein but Lower Fasting Glucose Concentrations.
M. Orho-Melander, O. Melander, C. Guiducci, P. Perez-Martinez, D. Corella, C. Roos, R. Tewhey, M. J. Rieder, J. Hall, G. Abecasis, et al. (2008)
Diabetes 57, 3112-3121
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Predicting Type 2 Diabetes Based on Polymorphisms From Genome-Wide Association Studies: A Population-Based Study.
M. van Hoek, A. Dehghan, J. C.M. Witteman, C. M. van Duijn, A. G. Uitterlinden, B. A. Oostra, A. Hofman, E. J.G. Sijbrands, and A. C. J.W. Janssens (2008)
Diabetes 57, 3122-3128
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Common Variation in the WNK1 Gene and Blood Pressure in Childhood: The Avon Longitudinal Study of Parents and Children.
M. D. Tobin, N. J. Timpson, L. V. Wain, S. Ring, L. R. Jones, P. M. Emmett, T. M. Palmer, A. R. Ness, N. J. Samani, G. D. Smith, et al. (2008)
Hypertension 52, 974-979
   Abstract »    Full Text »    PDF »


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