Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Published Online February 15, 2007
Science DOI: 10.1126/science.1136281

Research Articles

Submitted on October 13, 2006
Accepted on January 24, 2007

Human Neuroblasts Migrate to the Olfactory Bulb via a Lateral Ventricular Extension

Maurice A. Curtis 1, Monica Kam 2, Ulf Nannmark 3, Michelle F. Anderson 4, Mathilda Zetterstrom Axell 4, Carsten Wikkelso 4, Stig Holtås 5, Willeke M. C. van Roon-Mom 2, Thomas Björk-Eriksson 6, Claes Nordborg 7, Jonas Frisen Frisen 8, Michael Dragunow 9, Richard L. M. Faull 2*, Peter S. Eriksson 4*

1 Department of Anatomy with Radiology, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, Auckland, New Zealand; Center for Brain Repair and Rehabilitation, Institute of Neuroscience and Physiology
2 Department of Anatomy with Radiology, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, Auckland, New Zealand.
3 Institute of Biomedicine at Sahlgrenska Academy, Medicinaregatan 11, Box 432, SE 405 30 Göteborg, Sweden.
4 Center for Brain Repair and Rehabilitation, Institute of Neuroscience and Physiology
5 Department of Radiology, Bruna Stråket 11 plan 2, Sahlgrenska University Hospital, SE 413 45 Göteborg, Sweden.
6 Department of Oncology
7 Department of Pathology, Sahlgrenska University Hospital, 413 45 Göteborg, Sweden.
8 Department of Cell and Molecular Biology, Medical Nobel Institute, Karolinska Institute, SE-171 77 Stockholm, Sweden.
9 Department of Pharmacology, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, Auckland, New Zealand.

* To whom correspondence should be addressed.
Richard L. M. Faull , E-mail: rlm.faull{at}auckland.ac.nz
Peter S. Eriksson , E-mail: per{at}neuro.gu

The rostral migratory stream (RMS) is the main pathway by which newly born subventricular zone (SVZ) cells reach the olfactory bulb in rodents. However, the RMS in the adult human brain has been elusive. Here we demonstrate the presence of a human RMS, which is unexpectedly organized around a lateral ventricular extension reaching the olfactory bulb (OB), and illustrate the neuroblasts in it. The RMS ensheathing the lateral olfactory ventricular extension, as seen by MRI, cell specific markers and electron microscopy, contains progenitor cells with migratory characteristics and cells which incorporate BrdU and become mature neurons in the OB.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Maturation of the Olfactory Bulbs: MR Imaging Findings.
J.F. Schneider and F. Floemer (2009)
AJNR Am. J. Neuroradiol. 30, 1149-1152
   Abstract »    Full Text »    PDF »
L-Type Calcium Channels Govern Calcium Signaling in Migrating Newborn Neurons in the Postnatal Olfactory Bulb.
D. P. Darcy and J. S. Isaacson (2009)
J. Neurosci. 29, 2510-2518
   Abstract »    Full Text »    PDF »
Discovery of a functional protein complex of netrin-4, laminin {gamma}1 chain, and integrin {alpha}6{beta}1 in mouse neural stem cells.
F. I. Staquicini, E. Dias-Neto, J. Li, E. Y. Snyder, R. L. Sidman, R. Pasqualini, and W. Arap (2009)
PNAS 106, 2903-2908
   Abstract »    Full Text »    PDF »
Pten Deletion in Adult Neural Stem/Progenitor Cells Enhances Constitutive Neurogenesis.
C. Gregorian, J. Nakashima, J. Le Belle, J. Ohab, R. Kim, A. Liu, K. B. Smith, M. Groszer, A. D. Garcia, M. V. Sofroniew, et al. (2009)
J. Neurosci. 29, 1874-1886
   Abstract »    Full Text »    PDF »
A Nuclear Magnetic Resonance Biomarker for Neural Progenitor Cells: Is It All Neurogenesis?.
P. Ramm, S. Couillard-Despres, S. Plotz, F. J. Rivera, M. Krampert, B. Lehner, W. Kremer, U. Bogdahn, H. R. Kalbitzer, and L. Aigner (2009)
Stem Cells 27, 420-423
   Abstract »    Full Text »    PDF »
Stem Cells Use Distinct Self-renewal Programs at Different Ages.
B.P. Levi and S.J. Morrison (2009)
Cold Spring Harb Symp Quant Biol
   Abstract »    PDF »
The Heterogeneity of Adult Neural Stem Cells and the Emerging Complexity of Their Niche.
A. Alvarez-Buylla, M. Kohwi, T.M. Nguyen, and F.T. Merkle (2008)
Cold Spring Harb Symp Quant Biol
   Abstract »    PDF »
The nuclear receptor tailless is required for neurogenesis in the adult subventricular zone.
H.-K. Liu, T. Belz, D. Bock, A. Takacs, H. Wu, P. Lichter, M. Chai, and G. Schutz (2008)
Genes & Dev. 22, 2473-2478
   Abstract »    Full Text »    PDF »
Noninvasive and Quantitative Monitoring of Adult Neuronal Stem Cell Migration in Mouse Brain Using Bioluminescence Imaging.
V. Reumers, C. M. Deroose, O. Krylyshkina, J. Nuyts, M. Geraerts, L. Mortelmans, R. Gijsbers, C. Van den Haute, Z. Debyser, and V. Baekelandt (2008)
Stem Cells 26, 2382-2390
   Abstract »    Full Text »    PDF »
Control of neuroblast production and migration by converging GABA and glutamate signals in the postnatal forebrain.
J.-C. Platel, K. A. Dave, and A. Bordey (2008)
J. Physiol. 586, 3739-3743
   Abstract »    Full Text »    PDF »
Correlation of Olfactory Function With Changes in the Volume of the Human Olfactory Bulb.
A. Haehner, A. Rodewald, J. C. Gerber, and T. Hummel (2008)
Arch Otolaryngol Head Neck Surg 134, 621-624
   Abstract »    Full Text »    PDF »
Variant Brain-Derived Neurotrophic Factor (Val66Met) Alters Adult Olfactory Bulb Neurogenesis and Spontaneous Olfactory Discrimination.
K. G. Bath, N. Mandairon, D. Jing, R. Rajagopal, R. Kapoor, Z.-Y. Chen, T. Khan, C. C. Proenca, R. Kraemer, T. A. Cleland, et al. (2008)
J. Neurosci. 28, 2383-2393
   Abstract »    Full Text »    PDF »
Zeb1 links epithelial-mesenchymal transition and cellular senescence.
Y. Liu, S. El-Naggar, D. S. Darling, Y. Higashi, and D. C. Dean (2008)
Development 135, 579-588
   Abstract »    Full Text »    PDF »
Mature astrocytes in the adult human neocortex express the early neuronal marker doublecortin.
R. W. H. Verwer, A. A. Sluiter, R. A. Balesar, J. C. Baayen, D. P. Noske, C. M. F. Dirven, J. Wouda, A. M. van Dam, P. J. Lucassen, and D. F. Swaab (2007)
Brain 130, 3321-3335
   Abstract »    Full Text »    PDF »
Magnetic Resonance Spectroscopy Identifies Neural Progenitor Cells in the Live Human Brain.
L. N. Manganas, X. Zhang, Y. Li, R. D. Hazel, S. D. Smith, M. E. Wagshul, F. Henn, H. Benveniste, P. M. Djuric, G. Enikolopov, et al. (2007)
Science 318, 980-985
   Abstract »    Full Text »    PDF »
Diminished adult neurogenesis in the marmoset brain precedes old age.
B. Leuner, Y. Kozorovitskiy, C. G. Gross, and E. Gould (2007)
PNAS 104, 17169-17173
   Abstract »    Full Text »    PDF »
Comment on "Human Neuroblasts Migrate to the Olfactory Bulb via a Lateral Ventricular Extension".
N. Sanai, M. S. Berger, J. M. Garcia-Verdugo, and A. Alvarez-Buylla (2007)
Science 318, 393b
   Abstract »    Full Text »    PDF »
Response to Comment on "Human Neuroblasts Migrate to the Olfactory Bulb via a Lateral Ventricular Extension".
M. A. Curtis, M. Kam, U. Nannmark, R. L.M. Faull, and P. S. Eriksson (2007)
Science 318, 393c
   Abstract »    Full Text »    PDF »
Understanding the Regulation and Function of Adult Neurogenesis: Contribution from an Insect Model, the House Cricket.
M. Cayre, S. Scotto-Lomassese, J. Malaterre, C. Strambi, and A. Strambi (2007)
Chem Senses 32, 385-395
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)