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Published Online February 15, 2007
Science DOI: 10.1126/science.1136281

Research Articles

Submitted on October 13, 2006
Accepted on January 24, 2007

Human Neuroblasts Migrate to the Olfactory Bulb via a Lateral Ventricular Extension

Maurice A. Curtis 1, Monica Kam 2, Ulf Nannmark 3, Michelle F. Anderson 4, Mathilda Zetterstrom Axell 4, Carsten Wikkelso 4, Stig Holtås 5, Willeke M. C. van Roon-Mom 2, Thomas Björk-Eriksson 6, Claes Nordborg 7, Jonas Frisen Frisen 8, Michael Dragunow 9, Richard L. M. Faull 2*, Peter S. Eriksson 4*

1 Department of Anatomy with Radiology, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, Auckland, New Zealand; Center for Brain Repair and Rehabilitation, Institute of Neuroscience and Physiology
2 Department of Anatomy with Radiology, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, Auckland, New Zealand.
3 Institute of Biomedicine at Sahlgrenska Academy, Medicinaregatan 11, Box 432, SE 405 30 Göteborg, Sweden.
4 Center for Brain Repair and Rehabilitation, Institute of Neuroscience and Physiology
5 Department of Radiology, Bruna Stråket 11 plan 2, Sahlgrenska University Hospital, SE 413 45 Göteborg, Sweden.
6 Department of Oncology
7 Department of Pathology, Sahlgrenska University Hospital, 413 45 Göteborg, Sweden.
8 Department of Cell and Molecular Biology, Medical Nobel Institute, Karolinska Institute, SE-171 77 Stockholm, Sweden.
9 Department of Pharmacology, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, Auckland, New Zealand.

* To whom correspondence should be addressed.
Richard L. M. Faull , E-mail: rlm.faull{at}auckland.ac.nz
Peter S. Eriksson , E-mail: per{at}neuro.gu

The rostral migratory stream (RMS) is the main pathway by which newly born subventricular zone (SVZ) cells reach the olfactory bulb in rodents. However, the RMS in the adult human brain has been elusive. Here we demonstrate the presence of a human RMS, which is unexpectedly organized around a lateral ventricular extension reaching the olfactory bulb (OB), and illustrate the neuroblasts in it. The RMS ensheathing the lateral olfactory ventricular extension, as seen by MRI, cell specific markers and electron microscopy, contains progenitor cells with migratory characteristics and cells which incorporate BrdU and become mature neurons in the OB.


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