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Originally published in Science Express on 23 March 2006
Science 21 April 2006:
Vol. 312. no. 5772, p. 399
DOI: 10.1126/science.1125548
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H5N1 Virus Attachment to Lower Respiratory Tract

Debby van Riel, Vincent J. Munster, Emmie de Wit, Guus F. Rimmelzwaan, Ron A. M. Fouchier, Ab D. M. E. Osterhaus, Thijs Kuiken*

Highly pathogenic avian influenza virus (H5N1) may cause severe lower respiratory tract (LRT) disease in humans. However, the LRT cells to which the virus attaches are unknown for both humans and other mammals. We show here that H5N1 virus attached predominantly to type II pneumocytes, alveolar macrophages, and nonciliated bronchiolar cells in the human LRT, and this pattern was most closely mirrored in cat and ferret tissues. These findings may explain, at least in part, the localization and severity of H5N1 viral pneumonia in humans. They also identify the cat and the ferret as suitable experimental animals based on this criterion.

Department of Virology, Erasmus Medical Center, 3015 GE Rotterdam, Netherlands.

* To whom correspondence should be addressed. E-mail: t.kuiken{at}erasmusmc.nl

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Human Susceptiblity to H5N1 Avian Influenza and Virus Binding to the Lower Respiratory Tract
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Science Online, 12 Apr 2006 [Full text]

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