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Published Online January 26, 2006
Science DOI: 10.1126/science.1122864

Brevia

Submitted on November 21, 2005
Accepted on January 13, 2006

Prions in Skeletal Muscles of Deer with Chronic Wasting Disease

Rachel C. Angers 1, Shawn R. Browning 2, Tanya S. Seward 3, Christina J. Sigurdson 4, Michael W. Miller 5, Edward A. Hoover 6, Glenn C. Telling 7*

1 Department of Microbiology, Immunology and Molecular Genetics
2 Department of Microbiology, Immunology and Molecular Genetics; Present address: Department of Infectology, Scripps Research Institute, 5353 Parkside Drive, RF-2, Jupiter, Florida, 33458, USA.
3 Sanders Brown Center on Aging
4 Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA; Present address: Institute of Neuropathology, University of Zurich, Schmelzbergstrasse 12, 8091 Zurich, Switzerland.
5 Colorado Division of Wildlife, Wildlife Research Center, Fort Collins, CO 80526, USA.
6 Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA.
7 Department of Microbiology, Immunology and Molecular Genetics; Sanders Brown Center on Aging; Department of Neurology, University of Kentucky, Lexington, KY 40536, USA.

* To whom correspondence should be addressed.
Glenn C. Telling , E-mail: gtell2{at}uky.edu

The emergence of chronic wasting disease (CWD) of deer and elk in an increasingly wide geographic area and the interspecies transmission of bovine spongiform encephalopathy (BSE) to humans in the form of variant Creutzfeldt Jakob disease (vCJD) have raised concerns about the zoonotic potential of CWD. Since meat consumption is the most likely means of exposure, it is of considerable importance to determine whether skeletal muscle of diseased cervids contains prion infectivity. Here bioassays in transgenic mice expressing cervid prion protein revealed the presence of infectious prions in skeletal muscles of CWD-infected deer demonstrating that humans consuming or handling meat from CWD-infected deer are at risk to prion exposure.


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