Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Published Online January 26, 2006
Science DOI: 10.1126/science.1122864

Brevia

Submitted on November 21, 2005
Accepted on January 13, 2006

Prions in Skeletal Muscles of Deer with Chronic Wasting Disease

Rachel C. Angers 1, Shawn R. Browning 2, Tanya S. Seward 3, Christina J. Sigurdson 4, Michael W. Miller 5, Edward A. Hoover 6, Glenn C. Telling 7*

1 Department of Microbiology, Immunology and Molecular Genetics
2 Department of Microbiology, Immunology and Molecular Genetics; Present address: Department of Infectology, Scripps Research Institute, 5353 Parkside Drive, RF-2, Jupiter, Florida, 33458, USA.
3 Sanders Brown Center on Aging
4 Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA; Present address: Institute of Neuropathology, University of Zurich, Schmelzbergstrasse 12, 8091 Zurich, Switzerland.
5 Colorado Division of Wildlife, Wildlife Research Center, Fort Collins, CO 80526, USA.
6 Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA.
7 Department of Microbiology, Immunology and Molecular Genetics; Sanders Brown Center on Aging; Department of Neurology, University of Kentucky, Lexington, KY 40536, USA.

* To whom correspondence should be addressed.
Glenn C. Telling , E-mail: gtell2{at}uky.edu

The emergence of chronic wasting disease (CWD) of deer and elk in an increasingly wide geographic area and the interspecies transmission of bovine spongiform encephalopathy (BSE) to humans in the form of variant Creutzfeldt Jakob disease (vCJD) have raised concerns about the zoonotic potential of CWD. Since meat consumption is the most likely means of exposure, it is of considerable importance to determine whether skeletal muscle of diseased cervids contains prion infectivity. Here bioassays in transgenic mice expressing cervid prion protein revealed the presence of infectious prions in skeletal muscles of CWD-infected deer demonstrating that humans consuming or handling meat from CWD-infected deer are at risk to prion exposure.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Transmissible spongiform encephalopathy in the 21st century: Neuroscience for the clinical neurologist.
P. Brown (2008)
Neurology 70, 713-722
   Full Text »    PDF »
The elk PRNP codon 132 polymorphism controls cervid and scrapie prion propagation.
K. M. Green, S. R. Browning, T. S. Seward, J. E. Jewell, D. L. Ross, M. A. Green, E. S. Williams, E. A. Hoover, and G. C. Telling (2008)
J. Gen. Virol. 89, 598-608
   Abstract »    Full Text »    PDF »
Stromal Complement Receptor CD21/35 Facilitates Lymphoid Prion Colonization and Pathogenesis.
M. D. Zabel, M. Heikenwalder, M. Prinz, I. Arrighi, P. Schwarz, J. Kranich, A. von Teichman, K. M. Haas, N. Zeller, T. F. Tedder, et al. (2007)
J. Immunol. 179, 6144-6152
   Abstract »    Full Text »    PDF »
Prion Infection of Muscle Cells In Vitro.
W. M. Dlakic, E. Grigg, and R. A. Bessen (2007)
J. Virol. 81, 4615-4624
   Abstract »    Full Text »    PDF »
Resistance to Chronic Wasting Disease in Transgenic Mice Expressing a Naturally Occurring Allelic Variant of Deer Prion Protein.
K. Meade-White, B. Race, M. Trifilo, A. Bossers, C. Favara, R. Lacasse, M. Miller, E. Williams, M. Oldstone, R. Race, et al. (2007)
J. Virol. 81, 4533-4539
   Abstract »    Full Text »    PDF »
Colorado Surveillance Program for Chronic Wasting Disease Transmission to Humans: Lessons From 2 Highly Suspicious but Negative Cases.
C. A. Anderson, P. Bosque, C. M. Filley, D. B. Arciniegas, B. K. Kleinschmidt-DeMasters, W. J. Pape, and K. L. Tyler (2007)
Arch Neurol 64, 439-441
   Abstract »    Full Text »    PDF »
Strain Fidelity of Chronic Wasting Disease upon Murine Adaptation.
C. J. Sigurdson, G. Manco, P. Schwarz, P. Liberski, E. A. Hoover, S. Hornemann, M. Polymenidou, M. W. Miller, M. Glatzel, and A. Aguzzi (2006)
J. Virol. 80, 12303-12311
   Abstract »    Full Text »    PDF »
Passage of chronic wasting disease prion into transgenic mice expressing Rocky Mountain elk (Cervus elaphus nelsoni) PrPC.
G. LaFauci, R. I. Carp, H. C. Meeker, X. Ye, J. I. Kim, M. Natelli, M. Cedeno, R. B. Petersen, R. Kascsak, and R. Rubenstein (2006)
J. Gen. Virol. 87, 3773-3780
   Abstract »    Full Text »    PDF »
Prion protein in cardiac muscle of elk (Cervus elaphus nelsoni) and white-tailed deer (Odocoileus virginianus) infected with chronic wasting disease..
J. E. Jewell, J. Brown, T. Kreeger, and E. S. Williams (2006)
J. Gen. Virol. 87, 3443-3450
   Abstract »    Full Text »    PDF »
Patterns of PrPCWD accumulation during the course of chronic wasting disease infection in orally inoculated mule deer (Odocoileus hemionus)..
K. A. Fox, J. E. Jewell, E. S. Williams, and M. W. Miller (2006)
J. Gen. Virol. 87, 3451-3461
   Abstract »    Full Text »    PDF »
Transmission of elk and deer prions to transgenic mice..
G. Tamguney, K. Giles, E. Bouzamondo-Bernstein, P. J. Bosque, M. W. Miller, J. Safar, S. J. DeArmond, and S. B. Prusiner (2006)
J. Virol. 80, 9104-9114
   Abstract »    Full Text »    PDF »
Prions Found in Deer Muscle.
(2006)
Journal Watch Infectious Diseases 2006, 5
   Full Text »
Prions in Deer Muscle.
(2006)
Journal Watch (General) 2006, 4
   Full Text »
Potential Role of Soil in the Transmission of Prion Disease.
P. T. Schramm, C. J. Johnson, N. E. Mathews, D. McKenzie, J. M. Aiken, and J. A. Pedersen (2006)
Reviews in Mineralogy and Geochemistry 64, 135-152
   Full Text »    PDF »


ADVERTISEMENT
Click Me!

ADVERTISEMENT
Click Me!

To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)