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Published Online February 16, 2006
Science DOI: 10.1126/science.1122689

Research Articles

Submitted on November 16, 2005
Accepted on February 8, 2006

Zebrafish MiR-430 Promotes Deadenylation and Clearance of Maternal mRNAs

Antonio J. Giraldez 1*, Yuichiro Mishima 2, Jason Rihel 1, Russell J. Grocock 3, Stijn Van Dongen 4, Kunio Inoue 2, Anton J. Enright 3, Alexander F. Schier 1*

1 Developmental Genetics Program, Skirball Institute of Biomolecular Medicine and Department of Cell Biology, New York University School of Medicine New York, NY 10016. USA; Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, Massachusetts 02138.USA.
2 Department of Biology, Graduate School of Science and Technology, Kobe University, 1-1 Rokkodaicho, Nadaku, Kobe 657-8501, Japan.
3 Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.
4 Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.

* To whom correspondence should be addressed.
Antonio J. Giraldez , E-mail: giraldez{at}mcb.harvard.edu
Alexander F. Schier , E-mail: schier{at}fas.harvard.edu

MicroRNAs comprise 1-3% of all vertebrate genes, but their in vivo functions and mechanisms of action remain largely unknown. Zebrafish miR-430 is expressed at the onset of zygotic transcription and regulates morphogenesis during early development. Using a microarray approach and in vivo target validation, we find that miR-430 directly regulates several hundred target mRNAs. Most targets are maternally expressed mRNAs that accumulate in the absence of miR-430. We also show that miR-430 accelerates the deadenylation of target mRNAs. These results suggest that miR-430 facilitates the deadenylation and clearance of maternal mRNAs during early embryogenesis.


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