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Published Online September 29, 2005
Science DOI: 10.1126/science.1118391

Reports

Submitted on August 4, 2005
Accepted on September 20, 2005

Bats Are Natural Reservoirs of SARS-Like Coronaviruses

Wendong Li 1, Zhengli Shi 2*, Meng Yu 3, Wuze Ren 2, Craig Smith 4, Jonathan H. Epstein 5, Hanzhong Wang 2, Gary Crameri 3, Zhihong Hu 2, Huajun Zhang 2, Jianhong Zhang 2, Jennifer McEachern 3, Hume Field 4, Peter Daszak 5, Bryan T. Eaton 2, Shuyi Zhang 6*, Lin-Fa Wang 3*

1 Institute of Zoology of Chinese Academy of Sciences (CAS), Beijing, China; State Key Laboratory of Virology, Wuhan Institute of Virology, CAS, Wuhan, China.
2 State Key Laboratory of Virology, Wuhan Institute of Virology, CAS, Wuhan, China.
3 CSIRO Livestock Industries, Australian Animal Health Laboratory, Geelong, Australia.
4 Department of Primary Industries and Fisheries, Queensland, Australia.
5 The Consortium for Conservation Medicine, New York, USA.
6 Institute of Zoology of Chinese Academy of Sciences (CAS), Beijing, China; Guangzhou Institute of Biomedicine and Health, Guangzhou, China.

* To whom correspondence should be addressed.
Zhengli Shi , E-mail: zlshi{at}wh.iov.cn
Shuyi Zhang , E-mail: zhangsy{at}ioz.ac.cn
Lin-Fa Wang , E-mail: linfa.wang{at}csiro.au

Severe acute respiratory syndrome (SARS) emerged in 2002-3 in southern China. The origin of its etiological agent, the SARS coronavirus (SARS-CoV), remains elusive. Here we report that species of bats are a natural host of coronaviruses closely related to those responsible for the SARS outbreak. These viruses, termed SARS-like coronaviruses (SL-CoV), display greater genetic variation than SARS-CoV isolated from humans or civets. The human and civet isolates of SARS-CoV nestle phylogenetically within the spectrum of SL-CoVs, indicating that the virus responsible for the SARS outbreak was a member of this coronavirus group.


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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
Proteolytic Processing and Deubiquitinating Activity of Papain-Like Proteases of Human Coronavirus NL63.
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   Abstract »    Full Text »    PDF »
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Pathology and Pathogenesis of Severe Acute Respiratory Syndrome.
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
The ORF7b Protein of Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) Is Expressed in Virus-Infected Cells and Incorporated into SARS-CoV Particles.
S. R. Schaecher, J. M. Mackenzie, and A. Pekosz (2007)
J. Virol. 81, 718-731
   Abstract »    Full Text »    PDF »
Lethal Infection of K18-hACE2 Mice Infected with Severe Acute Respiratory Syndrome Coronavirus.
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   Abstract »    Full Text »    PDF »
Full-length genome sequences of two SARS-like coronaviruses in horseshoe bats and genetic variation analysis..
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   Abstract »    Full Text »    PDF »
Host heterogeneity dominates West Nile virus transmission.
A Marm Kilpatrick, P. Daszak, M. J Jones, P. P Marra, and L. D Kramer (2006)
Proc R Soc B 273, 2327-2333
   Abstract »    Full Text »    PDF »
Coronaviruses in bent-winged bats (Miniopterus spp.).
D. K. W. Chu, L. L. M. Poon, K. H. Chan, H. Chen, Y. Guan, K. Y. Yuen, and J. S. M. Peiris (2006)
J. Gen. Virol. 87, 2461-2466
   Abstract »    Full Text »    PDF »
Highly Conserved Regions within the Spike Proteins of Human Coronaviruses 229E and NL63 Determine Recognition of Their Respective Cellular Receptors..
H. Hofmann, G. Simmons, A. J. Rennekamp, C. Chaipan, T. Gramberg, E. Heck, M. Geier, A. Wegele, A. Marzi, P. Bates, et al. (2006)
J. Virol. 80, 8639-8652
   Abstract »    Full Text »    PDF »
Modulation of the unfolded protein response by the severe acute respiratory syndrome coronavirus spike protein..
C.-P. Chan, K.-L. Siu, K.-T. Chin, K.-Y. Yuen, B. Zheng, and D.-Y. Jin (2006)
J. Virol. 80, 9279-9287
   Abstract »    Full Text »    PDF »
Accumulation of Recombinant SARS-CoV Spike Protein in Plant Cytosol and Chloroplasts Indicate Potential for Development of Plant-Derived Oral Vaccines.
H.-Y. Li, S. Ramalingam, and M.-L. Chye (2006)
Experimental Biology and Medicine 231, 1346-1352
   Abstract »    Full Text »    PDF »
What we have learnt from SARS epidemics in China.
N. Zhong and G. Zeng (2006)
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Rewiring the severe acute respiratory syndrome coronavirus (SARS-CoV) transcription circuit: Engineering a recombination-resistant genome.
B. Yount, R. S. Roberts, L. Lindesmith, and R. S. Baric (2006)
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J. Virol. 80, 7287-7294
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Prevalence and genetic diversity of coronaviruses in bats from china..
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   Abstract »    Full Text »    PDF »
Cross-Neutralization of Human and Palm Civet Severe Acute Respiratory Syndrome Coronaviruses by Antibodies Targeting the Receptor-Binding Domain of Spike Protein.
Y. He, J. Li, W. Li, S. Lustigman, M. Farzan, and S. Jiang (2006)
J. Immunol. 176, 6085-6092
   Abstract »    Full Text »    PDF »
Animal Origins of the Severe Acute Respiratory Syndrome Coronavirus: Insight from ACE2-S-Protein Interactions.
W. Li, S.-K. Wong, F. Li, J. H. Kuhn, I-C. Huang, H. Choe, and M. Farzan (2006)
J. Virol. 80, 4211-4219
   Full Text »    PDF »
Avian Influenza: Virchow's Reminder.
C. Brown (2006)
Am. J. Pathol. 168, 6-8
   Full Text »    PDF »
Bats: The Missing SARS Reservoir.
(2005)
Journal Watch Pediatrics and Adolescent Medicine 2005, 11
   Full Text »
A walk on the wild side--emerging wildlife diseases.
A. A Cunningham (2005)
BMJ 331, 1214-1215
   Full Text »    PDF »
Bats: The Missing SARS Reservoir.
(2005)
Journal Watch Infectious Diseases 2005, 1
   Full Text »


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