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Published Online July 6, 2005
Science DOI: 10.1126/science.1115273

Brevia

Submitted on May 25, 2005
Accepted on June 29, 2005

Highly Pathogenic H5N1 Influenza Virus Infection in Migratory Birds

Jinhua Liu 1, Haixia Xiao 2, Fumin Lei 3, Qingyu Zhu 4, Kun Qin 1, Xiaowei Zhang 5, Xinglin Zhang 1, Deming Zhao 1, Guihua Wang 2, Youjun Feng 2, Juncai Ma 6, Wenjun Liu 6, Jian Wang 5, George F. Gao 6*

1 College of Veterinary Medicine, China Agricultural University, Beijing 100094, China.
2 Institute of Microbiology, Chinese Academy of Sciences, Beijing 100080, China; Graduate School, Chinese Academy of Sciences, Beijing, China.
3 Institute of Zoology, Chinese Academy of Sciences, Beijing 100080, China.
4 Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing 100071, China.
5 Beijing Genomics Institute, Chinese Academy of Sciences, 101300, China.
6 Institute of Microbiology, Chinese Academy of Sciences, Beijing 100080, China.

* To whom correspondence should be addressed.
George F. Gao , E-mail: gaof{at}im.ac.cn

H5N1 avian influenza virus (AIV) has emerged as a pathogenic entity for a variety of species, including humans, in recent years. Here we report an outbreak among migratory birds on Lake Qinghaihu, China, in May and June 2005, in which hundreds of thousands of birds were affected. Pancreatic necrosis and abnormal neurological symptoms were the major clinical features. Sequencing of complete genomes of four H5N1 AIV strains isolated revealed to be reassortants related to a peregrine falcon isolate from Hong Kong and showed known "highly pathogenic" characteristics. Experimental animal infections reproduced typical highly pathogenic AIV-infection symptoms and pathology.


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