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Published Online July 28, 2005
Science DOI: 10.1126/science.1114580

Reports

Submitted on May 9, 2005
Accepted on July 19, 2005

Plague Bacteria Target Immune Cells During Infection

Melanie M. Marketon 1, R. William DePaolo 2, Kristin L. DeBord 1, Bana Jabri 2, Olaf Schneewind 1*

1 Department of Microbiology
2 Department of Pathology, University of Chicago, Chicago, IL 60637, USA.

* To whom correspondence should be addressed.
Olaf Schneewind , E-mail: oschnee{at}bsd.uchicago.edu

The plague is caused by the bacterium Yersinia pestis. Plague bacteria are thought to inject so called effector Yops via the type III pathway into host cells. The identity of host cells targeted for injection during plague infection is unknown. We found, using Yop {beta}-lactamase hybrids and fluorescent staining of live cells from plague infected animals, that Y. pestis selected immune cells for injection. In vivo, dendritic cells, macrophages and neutrophils were injected most frequently, whereas B and T lymphocytes were rarely selected. Thus, it appears that Y. pestis disable these cell populations to annihilate host immune responses during plague.


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