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Published Online June 23, 2005
Science DOI: 10.1126/science.1109977

Reports

Submitted on January 19, 2005
Accepted on June 9, 2005

Antagonistic Control of Disease Resistance Protein Stability in the Plant Immune System

Ben F. Holt III 1, Youssef Belkhadir 1, Jeffery L. Dangl 2*

1 Department of Biology
2 Department of Biology; Curriculum in Genetics; Department of Microbiology and Immunology; Carolina Center for Genome Sciences, University of North Carolina, Chapel Hill, NC 27599, USA.

* To whom correspondence should be addressed.
Jeffery L. Dangl , E-mail: dangl{at}email.unc.edu

Pathogen recognition by the plant immune system is governed by structurally related, polymorphic products of disease resistance (R) genes. RAR1 and/or SGT1b mediate the function of many R proteins. RAR1 controls pre-activation R protein accumulation by an unknown mechanism. We demonstrate that Arabidopsis SGT1b has two distinct, genetically separable functions in the plant immune system: SGT1b antagonizes RAR1 to negatively regulate R protein accumulation before infection, and SGT1b has a RAR1-independent function that regulates programmed cell death during infection. The balanced activities of RAR1 and SGT1, in concert with cytosolic HSP90, modulate pre-activation R protein accumulation and signaling competence.


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