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Originally published in Science Express on 21 April 2005
Science 13 May 2005:
Vol. 308. no. 5724, pp. 1043 - 1045
DOI: 10.1126/science.1108750
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Obesity and Metabolic Syndrome in Circadian Clock Mutant Mice

Fred W. Turek,1,3 Corinne Joshu,3,4* Akira Kohsaka,3,4* Emily Lin,3,4* Ganka Ivanova,2,4 Erin McDearmon,3,5 Aaron Laposky,3 Sue Losee-Olson,3 Amy Easton,3 Dalan R. Jensen,6 Robert H. Eckel,6 Joseph S. Takahashi,1,3,5 Joseph Bass2,3,4{dagger}

The CLOCK transcription factor is a key component of the molecular circadian clock within pacemaker neurons of the hypothalamic suprachiasmatic nucleus. We found that homozygous Clock mutant mice have a greatly attenuated diurnal feeding rhythm, are hyperphagic and obese, and develop a metabolic syndrome of hyperleptinemia, hyperlipidemia, hepatic steatosis, hyperglycemia, and hypoinsulinemia. Expression of transcripts encoding selected hypothalamic peptides associated with energy balance was attenuated in the Clock mutant mice. These results suggest that the circadian clock gene network plays an important role in mammalian energy balance.

1 Department of Neurology, Northwestern University, Evanston, IL 60208, USA.
2 Department of Medicine, Feinberg School of Medicine, Northwestern University, Evanston, IL 60208, USA.
3 Department of Neurobiology and Physiology, Northwestern University, Evanston, IL 60208, USA.
4 Evanston Northwestern Healthcare (ENH) Research Institute, Evanston, IL 60208, USA.
5 Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.
6 Department of Medicine, University of Colorado at Denver and Health Sciences Center, Aurora, CO 80045, USA.

Published online 21 April 2005

Include this information when citing this paper.

* These authors contributed equally to this work.

{dagger} To whom correspondence should be addressed. E-mail: j-bass{at}northwestern.edu

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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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X. Pan and M. M. Hussain (2009)
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    PDF »
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M. J Prasai, J. T George, and E. M Scott (2008)
Diabetes and Vascular Disease Research 5, 89-95
   Abstract »    PDF »
Loss of prokineticin receptor 2 signaling predisposes mice to torpor.
P. H. Jethwa, H. I'Anson, A. Warner, H. M. Prosser, M. H. Hastings, E. S. Maywood, and F. J. P. Ebling (2008)
Am J Physiol Regulatory Integrative Comp Physiol 294, R1968-R1979
   Abstract »    Full Text »    PDF »
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C. Bertolucci, N. Cavallari, I. Colognesi, J. Aguzzi, Z. Chen, P. Caruso, A. Foa, G. Tosini, F. Bernardi, and M. Pinotti (2008)
Mol. Cell. Biol. 28, 3070-3075
   Abstract »    Full Text »    PDF »
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F. W. Turek (2008)
Am J Physiol Regulatory Integrative Comp Physiol 294, R1672-R1674
   Full Text »    PDF »
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V. Pilorz and S. Steinlechner (2008)
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   Abstract »    Full Text »    PDF »
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M. Brunner and M. Merrow (2008)
Genes & Dev. 22, 825-831
   Full Text »    PDF »
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J. A. Levine, S. K. McCrady, L. M. Lanningham-Foster, P. H. Kane, R. C. Foster, and C. U. Manohar (2008)
Diabetes 57, 548-554
   Abstract »    Full Text »    PDF »
Sleep duration, general and abdominal obesity, and weight change among the older adult population of Spain.
E. Lopez-Garcia, R. Faubel, L. Leon-Munoz, M. C Zuluaga, J. R Banegas, and F. Rodriguez-Artalejo (2008)
Am. J. Clinical Nutrition 87, 310-316
   Abstract »    Full Text »    PDF »
Metabolic rhythm abnormalities in mice lacking VIP-VPAC2 signaling.
D. A. Bechtold, T. M. Brown, S. M. Luckman, and H. D. Piggins (2008)
Am J Physiol Regulatory Integrative Comp Physiol 294, R344-R351
   Abstract »    Full Text »    PDF »
Disruption of the circadian clock within the cardiomyocyte influences myocardial contractile function, metabolism, and gene expression.
M. S. Bray, C. A. Shaw, M. W. S. Moore, R. A. P. Garcia, M. M. Zanquetta, D. J. Durgan, W. J. Jeong, J.-Y. Tsai, H. Bugger, D. Zhang, et al. (2008)
Am J Physiol Heart Circ Physiol 294, H1036-H1047
   Abstract »    Full Text »    PDF »
Clock mutation facilitates accumulation of cholesterol in the liver of mice fed a cholesterol and/or cholic acid diet.
T. Kudo, M. Kawashima, T. Tamagawa, and S. Shibata (2008)
Am J Physiol Endocrinol Metab 294, E120-E130
   Abstract »    Full Text »    PDF »
Rev-erb{alpha}, a Heme Sensor That Coordinates Metabolic and Circadian Pathways.
L. Yin, N. Wu, J. C. Curtin, M. Qatanani, N. R. Szwergold, R. A. Reid, G. M. Waitt, D. J. Parks, K. H. Pearce, G. B. Wisely, et al. (2007)
Science 318, 1786-1789
   Abstract »    Full Text »    PDF »
Inactivation of the mouse Magel2 gene results in growth abnormalities similar to Prader-Willi syndrome.
J. M. Bischof, C. L. Stewart, and R. Wevrick (2007)
Hum. Mol. Genet. 16, 2713-2719
   Abstract »    Full Text »    PDF »
Thrombomodulin Is a Clock-controlled Gene in Vascular Endothelial Cells.
N. Takeda, K. Maemura, S. Horie, K. Oishi, Y. Imai, T. Harada, T. Saito, T. Shiga, E. Amiya, I. Manabe, et al. (2007)
J. Biol. Chem. 282, 32561-32567
   Abstract »    Full Text »    PDF »
Circadian clocks: regulators of endocrine and metabolic rhythms.
M. Hastings, J. S O'Neill, and E. S Maywood (2007)
J. Endocrinol. 195, 187-198
   Abstract »    Full Text »    PDF »
Effect of deficiency in SREBP cleavage-activating protein on lipid metabolism during intermittent hypoxia.
J. Li, A. Nanayakkara, J. Jun, V. Savransky, and V. Y. Polotsky (2007)
Physiol Genomics 31, 273-280
   Abstract »    Full Text »    PDF »
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S. Sookoian and C. J. Pirola (2007)
Therapeutic Advances in Cardiovascular Disease 1, 37-47
   Abstract »    PDF »
Metabolic homeostasis in mice with disrupted Clock gene expression in peripheral tissues.
D. J. Kennaway, J. A. Owens, A. Voultsios, M. J. Boden, and T. J. Varcoe (2007)
Am J Physiol Regulatory Integrative Comp Physiol 293, R1528-R1537
   Abstract »    Full Text »    PDF »
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T. Kudo, T. Tamagawa, M. Kawashima, N. Mito, and S. Shibata (2007)
J Biol Rhythms 22, 312-323
   Abstract »    PDF »
Peripheral Circadian Clocks in the Vasculature.
D. F. Reilly, E. J. Westgate, and G. A. FitzGerald (2007)
Arterioscler Thromb Vasc Biol 27, 1694-1705
   Abstract »    Full Text »    PDF »
Mechanisms of obesity-associated insulin resistance: many choices on the menu.
M. Qatanani and M. A. Lazar (2007)
Genes & Dev. 21, 1443-1455
   Abstract »    Full Text »    PDF »
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C. B. Green, N. Douris, S. Kojima, C. A. Strayer, J. Fogerty, D. Lourim, S. R. Keller, and J. C. Besharse (2007)
PNAS 104, 9888-9893
   Abstract »    Full Text »    PDF »
Insulin Resistance Concepts.
Z. T. Bloomgarden (2007)
Diabetes Care 30, 1320-1326
   Full Text »    PDF »
Mutation of the Circadian Clock Gene Per2 Alters Vascular Endothelial Function.
H. Viswambharan, J. M. Carvas, V. Antic, A. Marecic, C. Jud, C. E. Zaugg, X.-F. Ming, J.-P. Montani, U. Albrecht, and Z. Yang (2007)
Circulation 115, 2188-2195
   Abstract »    Full Text »    PDF »
Inter-subject differences in constitutive expression levels of the clock gene in man.
A. J Balmforth, P. J Grant, E. M Scott, S. B Wheatcroft, M. T Kearney, B. Staels, and N. Marx (2007)
Diabetes and Vascular Disease Research 4, 39-43
   Abstract »    PDF »
Circadian and CLOCK-controlled regulation of the mouse transcriptome and cell proliferation.
B. H. Miller, E. L. McDearmon, S. Panda, K. R. Hayes, J. Zhang, J. L. Andrews, M. P. Antoch, J. R. Walker, K. A. Esser, J. B. Hogenesch, et al. (2007)
PNAS 104, 3342-3347
   Abstract »    Full Text »    PDF »
Principles and Problems Revolving Round Rhythm-related Genetic Variants.
J. C. Hall, D. C. Chang, and E. Dolezelova (2007)
Cold Spring Harb Symp Quant Biol 72, 215-232
   Abstract »    PDF »
Reversible Protein Phosphorylation Regulates Circadian Rhythms.
D. M. Virshup, E. J. Eide, D. B. Forger, M. Gallego, and E. V. Harnish (2007)
Cold Spring Harb Symp Quant Biol 72, 413-420
   Abstract »    PDF »
The Clock Proteins, Aging, and Tumorigenesis.
R. V. Kondratov and M. P. Antoch (2007)
Cold Spring Harb Symp Quant Biol 72, 477-482
   Abstract »    PDF »
Role for the Clock Gene in Bipolar Disorder.
C. A. McClung (2007)
Cold Spring Harb Symp Quant Biol 72, 637-644
   Abstract »    PDF »
SCN Outputs and the Hypothalamic Balance of Life.
A. Kalsbeek, I. F. Palm, S. E. La Fleur, F. A. J. L. Scheer, S. Perreau-Lenz, M. Ruiter, F. Kreier, C. Cailotto, and R. M. Buijs (2006)
J Biol Rhythms 21, 458-469
   Abstract »    PDF »
Properties, Entrainment, and Physiological Functions of Mammalian Peripheral Oscillators.
M. Stratmann and U. Schibler (2006)
J Biol Rhythms 21, 494-506
   Abstract »    PDF »
Coordinated multitissue transcriptional and plasma metabonomic profiles following acute caloric restriction in mice.
C. Selman, N. D. Kerrison, A. Cooray, M. D. W. Piper, S. J. Lingard, R. H. Barton, E. F. Schuster, E. Blanc, D. Gems, J. K. Nicholson, et al. (2006)
Physiol Genomics 27, 187-200
   Abstract »    Full Text »    PDF »
Association between Reduced Sleep and Weight Gain in Women.
S. R. Patel, A. Malhotra, D. P. White, D. J. Gottlieb, and F. B. Hu (2006)
Am. J. Epidemiol. 164, 947-954
   Abstract »    Full Text »    PDF »
Long-lived {alpha}MUPA transgenic mice exhibit pronounced circadian rhythms.
O. Froy, N. Chapnik, and R. Miskin (2006)
Am J Physiol Endocrinol Metab 291, E1017-E1024
   Abstract »    Full Text »    PDF »
Molecular components of the mammalian circadian clock.
C. H. Ko and J. S. Takahashi (2006)
Hum. Mol. Genet. 15, R271-R277
   Abstract »    Full Text »    PDF »
PAI-1 and the Metabolic Syndrome: Links, Causes, and Consequences.
M.-C. Alessi and I. Juhan-Vague (2006)
Arterioscler Thromb Vasc Biol 26, 2200-2207
   Abstract »    Full Text »    PDF »
Functional central rhythmicity and light entrainment, but not liver and muscle rhythmicity, are Clock independent.
D. J. Kennaway, J. A. Owens, A. Voultsios, and T. J. Varcoe (2006)
Am J Physiol Regulatory Integrative Comp Physiol 291, R1172-R1180
   Abstract »    Full Text »    PDF »
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M. J Boden and D. J Kennaway (2006)
Reproduction 132, 379-392
   Abstract »    Full Text »    PDF »
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T. Kawamoto, M. Noshiro, M. Furukawa, K. K. Honda, A. Nakashima, T. Ueshima, E. Usui, Y. Katsura, K. Fujimoto, S. Honma, et al. (2006)
J. Biochem. 140, 401-408
   Abstract »    Full Text »    PDF »
The dorsomedial hypothalamic nucleus as a putative food-entrainable circadian pacemaker.
M. Mieda, S. C. Williams, J. A. Richardson, K. Tanaka, and M. Yanagisawa (2006)
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   Abstract »    Full Text »    PDF »
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   Full Text »    PDF »
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L. Canaple, J. Rambaud, O. Dkhissi-Benyahya, B. Rayet, N. S. Tan, L. Michalik, F. Delaunay, W. Wahli, and V. Laudet (2006)
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   Abstract »    Full Text »    PDF »
Early aging and age-related pathologies in mice deficient in BMAL1, the core componentof the circadian clock.
R. V. Kondratov, A. A. Kondratova, V. Y. Gorbacheva, O. V. Vykhovanets, and M. P. Antoch (2006)
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   Abstract »    Full Text »    PDF »
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M. Gallego, E. J. Eide, M. F. Woolf, D. M. Virshup, and D. B. Forger (2006)
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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S. Zvonic, A. A. Ptitsyn, S. A. Conrad, L. K. Scott, Z. E. Floyd, G. Kilroy, X. Wu, B. C. Goh, R. L. Mynatt, and J. M. Gimble (2006)
Diabetes 55, 962-970
   Abstract »    Full Text »    PDF »
Sleep disruption is related to allelic variation in the ob gene.
R. Lydic (2006)
Am J Physiol Regulatory Integrative Comp Physiol 290, R892-R893
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Circadian Clock Mutation in Dams Disrupts Nursing Behavior and Growth of Pups.
K. Hoshino, Y. Wakatsuki, M. Iigo, and S. Shibata (2006)
Endocrinology 147, 1916-1923
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Altered sleep regulation in leptin-deficient mice.
A. D. Laposky, J. Shelton, J. Bass, C. Dugovic, N. Perrino, and F. W. Turek (2006)
Am J Physiol Regulatory Integrative Comp Physiol 290, R894-R903
   Abstract »    Full Text »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)