Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
Invitrogen

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Originally published in Science Express on 26 August 2004
Science 24 September 2004:
Vol. 305. no. 5692, pp. 1963 - 1966
DOI: 10.1126/science.1102421
Prev | Table of Contents | Next

Reports

Soma-Germ Line Competition for Lipid Phosphate Uptake Regulates Germ Cell Migration and Survival

A. D. Renault,1 Y. J. Sigal,2 A. J. Morris,2 R. Lehmann1*

Lipid phosphates can act as signaling molecules to influence cell division, apoptosis, and migration. wunen and wunen2 encode Drosophila lipid phosphate phosphohydrolases, integral membrane enzymes that dephosphorylate extracellular lipid phosphates. wun and wun2 act redundantly in somatic tissues to repel migrating germ cells, although the mechanism by which germ cells respond is unclear. Here, we report that wun2 also functions in germ cells, enabling them to perceive the wun/wun2–related signal from the soma. Upon Wun2 expression, cultured insect cells dephosphorylate and internalize exogenously supplied lipid phosphate. We propose that Drosophila germ cell migration and survival are controlled by competition for hydrolysis of a lipid phosphate between germ cells and soma.

1 Howard Hughes Medical Institute, Developmental Genetics Program, Skirball Institute and Department of Cell Biology, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA.
2 Department of Cell and Developmental Biology, Room 522, Taylor Hall, CB#7090, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599–7090, USA.

* To whom correspondence should be addressed. E-mail address: lehmann{at}saturn.med.nyu.edu

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Programmed cell death of primordial germ cells in Drosophila is regulated by p53 and the Outsiders monocarboxylate transporter.
Y. Yamada, K. D. Davis, and C. R. Coffman (2008)
Development 135, 207-216
   Abstract »    Full Text »    PDF »
Maternal Nanos represses hid/skl-dependent apoptosis to maintain the germ line in Drosophila embryos.
K. Sato, Y. Hayashi, Y. Ninomiya, S. Shigenobu, K. Arita, M. Mukai, and S. Kobayashi (2007)
PNAS 104, 7455-7460
   Abstract »    Full Text »    PDF »
What Is Left Behind--Quality Control in Germ Cell Migration.
B. Boldajipour and E. Raz (2007)
Sci. STKE 2007, pe16
   Abstract »    Full Text »    PDF »
Lipid Phosphate Phosphatase-1 Regulates Lysophosphatidate-induced Fibroblast Migration by Controlling Phospholipase D2-dependent Phosphatidate Generation.
C. Pilquil, J. Dewald, A. Cherney, I. Gorshkova, G. Tigyi, D. English, V. Natarajan, and D. N. Brindley (2006)
J. Biol. Chem. 281, 38418-38429
   Abstract »    Full Text »    PDF »
Lipid Phosphate Phosphatase-2 Activity Regulates S-phase Entry of the Cell Cycle in Rat2 Fibroblasts.
K. E. Morris, L. M. Schang, and D. N. Brindley (2006)
J. Biol. Chem. 281, 9297-9306
   Abstract »    Full Text »    PDF »
Control of lateral migration and germ cell elimination by the Drosophila melanogaster lipid phosphate phosphatases Wunen and Wunen 2.
H. Sano, A. D. Renault, and R. Lehmann (2005)
J. Cell Biol. 171, 675-683
   Abstract »    Full Text »    PDF »
Lymphocyte Sequestration Through S1P Lyase Inhibition and Disruption of S1P Gradients.
S. R. Schwab, J. P. Pereira, M. Matloubian, Y. Xu, Y. Huang, and J. G. Cyster (2005)
Science 309, 1735-1739
   Abstract »    Full Text »    PDF »


ADVERTISEMENT
Click Me!

ADVERTISEMENT
Click Me!

To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)