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Published Online November 4, 2004
Science DOI: 10.1126/science.1101675

Reports

Submitted on June 18, 2004
Accepted on October 27, 2004

Y Chromosome of D. pseudoobscura Is Not Homologous to the Ancestral Drosophila Y

Antonio Bernardo Carvalho 1* and Andrew G. Clark 2

1 Departamento de Genética, Universidade Federal do Rio de Janeiro, Caixa Postal 68011, CEP 21944-970, Rio de Janeiro, Brazil.
2 Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA.

* To whom correspondence should be addressed.
Antonio Bernardo Carvalho , E-mail: bernardo{at}biologia.ufrj.br

We report a genome-wide search of Y-linked genes in Drosophila pseudoobscura. All six identifiable orthologs of the D. melanogaster Y-linked genes have autosomal inheritance in D. pseudoobscura. Four orthologs were investigated in detail and proved to be Y-linked in D. guanche and D. bifasciata, which shows that less than 18 million years ago the ancestral Drosophila Y-chromosome was translocated to an autosome in the D. pseudoobscura lineage. We found 15 genes and pseudogenes in the current Y of D. pseudoobscura, and none are shared with the D. melanogaster Y. Hence, the Y chromosome in the D. pseudoobscura lineage appears to have arisen de novo and is not homologous to the D. melanogaster Y.


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Science. ISSN 0036-8075 (print), 1095-9203 (online)