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Published Online March 11, 2004
Science DOI: 10.1126/science.1096502

Brevia

Submitted on February 6, 2004
Accepted on February 27, 2004

High Frequency of Mutations of the PIK3CA Gene in Human Cancers

Yardena Samuels 1, Zhenghe Wang 1, Alberto Bardelli 1, Natalie Silliman 1, Janine Ptak 1, Steve Szabo 1, Hai Yan 2, Adi Gazdar 3, Steven M. Powell 4, Gregory J. Riggins 1, James K.V. Willson 5, Sanford Markowitz 5, Kenneth W. Kinzler 1, Bert Vogelstein 1, Victor E. Velculescu 1*

1 The Sidney Kimmel Comprehensive Cancer Center and The Howard Hughes Medical Institute, The Johns Hopkins University Medical Institutions, Baltimore, MD 21231, USA.
2 Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA.
3 Hamon Center for Therapeutic Oncology Research and Dept. of Pathology, UT Southwestern Medical Center, Dallas TX 75390, USA.
4 Division of Gastroenterology/Hepatology, UVA Health System, Charlottesville, VA 22908, USA.
5 Howard Hughes Medical Institute and Ireland Cancer Center, University Hospitals of Cleveland and Case Western University, Cleveland, OH 44106, USA.

* To whom correspondence should be addressed. E-mail: velculescu{at}jhmi.edu.

A gene coding for a well-known lipid kinase is frequently mutated in human tumors, offering a new target for cancer diagnosis and therapy.


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J Natl Cancer Inst 98, 545-556
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KRAS Mutation Status Is Predictive of Response to Cetuximab Therapy in Colorectal Cancer..
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Cancer Res. 66, 3992-3995
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Combined cDNA array comparative genomic hybridization and serial analysis of gene expression analysis of breast tumor progression..
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Cancer Res. 66, 4065-4078
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PIK3CA Mutations in Head and Neck Squamous Cell Carcinoma.
W. Qiu, F. Schonleben, X. Li, D. J. Ho, L. G. Close, S. Manolidis, B. P. Bennett, and G. H. Su (2006)
Clin. Cancer Res. 12, 1441-1446
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Tetraspanin CD9 regulates invasion during mouse embryo implantation.
W M Liu, Y J Cao, Y J Yang, J Li, Z Hu, and E-K Duan (2006)
J. Mol. Endocrinol. 36, 121-130
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