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Published Online March 4, 2004
Science DOI: 10.1126/science.1095781

Reports

Submitted on January 20, 2004
Accepted on February 24, 2004

The Ashbya gossypii Genome as a Tool for Mapping the Ancient Saccharomyces cerevisiae Genome

Fred S. Dietrich 1, Sylvia Voegeli 2, Sophie Brachat 2, Anita Lerch 2, Krista Gates 3, Sabine Steiner 2, Christine Mohr 2, Rainer Pöhlmann 2, Philippe Luedi 1, Sangdun Choi 4, Rod A. Wing 4, Albert Flavier 3, Thomas D. Gaffney 3, Peter Philippsen 2*

1 Biozentrum der Universität Basel, Klingelbergstrasse 50, CH-4056 Basel, Switzerland; Department of Molecular Genetics and Microbiology, Duke University Medical Center, Research Drive, Durham, NC 27710, USA.
2 Biozentrum der Universität Basel, Klingelbergstrasse 50, CH-4056 Basel, Switzerland.
3 Syngenta Biotechnology Inc., 3054 Cornwallis Road, Research Triangle Park, NC 27709, USA.
4 Departments of Agronomy and Biological Sciences, Clemson University, Clemson, SC 29634, USA.

* To whom correspondence should be addressed. E-mail: Peter.philippsen{at}unibas.ch.

We have sequenced and annotated the genome of the filamentous ascomycete Ashbya gossypii. With a size of only 9.2 Mb, encoding 4718 protein coding genes, it is the smallest genome of a free-living eukaryote yet characterized. Over 90% of A. gossypii genes show both homology and a particular pattern of synteny with Saccharomyces cerevisiae. Analysis of this pattern revealed 300 inversions and translocations that have occurred since divergence of these two species. It also provided compelling evidence that the evolution of S. cerevisiae included a whole genome duplication or fusion of two related species, and showed, based on inferred ancient gene orders, which of the duplicated genes lost one copy and which retained both copies.


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