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Published Online April 8, 2004
Science DOI: 10.1126/science.1095760

Research Articles

Submitted on January 20, 2004
Accepted on March 3, 2004

Independent Cellular Processes for Hippocampal Memory Consolidation and Reconsolidation

Jonathan L. C. Lee 1, Barry J. Everitt 1, Kerrie L. Thomas 2*

1 Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB2 3EB, UK.
2 Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB2 3EB, UK; Present address: Cardiff School of Biosciences, Cardiff University, Cardiff CF10 3US, UK.

* To whom correspondence should be addressed.
Kerrie L. Thomas , E-mail: thomaskl5{at}cf.ac.uk

The idea that new memories undergo a time-dependent consolidation process after acquisition has received considerable experimental support. More controversial has been the demonstration that established memories, once recalled, become labile and sensitive to disruption, requiring "reconsolidation" to become permanent. By infusing antisense oligodeoxynucleotides into the hippocampus we show that consolidation and reconsolidation are doubly dissociable component processes of memory. Consolidation involves brain-derived neurotrophic factor (BDNF) but not Zif268, whereas reconsolidation recruits Zif268 but not BDNF. These experimental findings confirm a requirement for BDNF specifically in memory consolidation, and also resolves the role of Zif268 in brain plasticity, learning and memory.


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